The role of alpha and beta adrenergic receptors in constriction and dilation of the systemic capacitance vessels: A study with measurements of the mean circulatory pressure in dogs

Senri Hirakawa, Hiroyasu Itoh, Yasunori Kotoo, Chikashi Abe, Toyohiro Endo, Nobuyuki Takada, Hideo Fuseno

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The response of the mean circulatory pressure (MCP), an index of the tone of the systemic capacitance vessels, to the infusion of an alpha-adrenergic receptor stimulant (phenylephrine) and a beta-adrenergic receptor stimulant (isoproterenol) was studied in anesthetized, open-chest dogs. Provided that the blood volume (particularly, extra volume) remains constant, an increase in the MCP indicates an increase in the tone of the capacitance vessels (“venoconstriction”) and a decrease in the MCP indicates a decrease in the tone of the capacitance vessels (“venodilation”). It was almost definitely concluded that the stimulation of the alpha-adrenergic receptor led to the increased tone of the systemic capacitance vessels and the stimulation of the beta-adrenergic receptor did not decrease the tone of the systemic capacitance vessels in anesthetized, open-chest dogs, but the stimulation of the beta-adrenergic receptor decreased the tone of the systemic capacitance vessels, when the tone had been previously elevated by angiotensin-II.

Original languageEnglish
Pages (from-to)620-632
Number of pages13
JournalJAPANESE CIRCULATION JOURNAL
Volume48
Issue number7
DOIs
Publication statusPublished - 01-1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

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