TY - JOUR
T1 - The role of alpha and beta adrenergic receptors in constriction and dilation of the systemic capacitance vessels
T2 - A study with measurements of the mean circulatory pressure in dogs
AU - Hirakawa, Senri
AU - Itoh, Hiroyasu
AU - Kotoo, Yasunori
AU - Abe, Chikashi
AU - Endo, Toyohiro
AU - Takada, Nobuyuki
AU - Fuseno, Hideo
PY - 1984/1
Y1 - 1984/1
N2 - The response of the mean circulatory pressure (MCP), an index of the tone of the systemic capacitance vessels, to the infusion of an alpha-adrenergic receptor stimulant (phenylephrine) and a beta-adrenergic receptor stimulant (isoproterenol) was studied in anesthetized, open-chest dogs. Provided that the blood volume (particularly, extra volume) remains constant, an increase in the MCP indicates an increase in the tone of the capacitance vessels (“venoconstriction”) and a decrease in the MCP indicates a decrease in the tone of the capacitance vessels (“venodilation”). It was almost definitely concluded that the stimulation of the alpha-adrenergic receptor led to the increased tone of the systemic capacitance vessels and the stimulation of the beta-adrenergic receptor did not decrease the tone of the systemic capacitance vessels in anesthetized, open-chest dogs, but the stimulation of the beta-adrenergic receptor decreased the tone of the systemic capacitance vessels, when the tone had been previously elevated by angiotensin-II.
AB - The response of the mean circulatory pressure (MCP), an index of the tone of the systemic capacitance vessels, to the infusion of an alpha-adrenergic receptor stimulant (phenylephrine) and a beta-adrenergic receptor stimulant (isoproterenol) was studied in anesthetized, open-chest dogs. Provided that the blood volume (particularly, extra volume) remains constant, an increase in the MCP indicates an increase in the tone of the capacitance vessels (“venoconstriction”) and a decrease in the MCP indicates a decrease in the tone of the capacitance vessels (“venodilation”). It was almost definitely concluded that the stimulation of the alpha-adrenergic receptor led to the increased tone of the systemic capacitance vessels and the stimulation of the beta-adrenergic receptor did not decrease the tone of the systemic capacitance vessels in anesthetized, open-chest dogs, but the stimulation of the beta-adrenergic receptor decreased the tone of the systemic capacitance vessels, when the tone had been previously elevated by angiotensin-II.
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U2 - 10.1253/jcj.48.620
DO - 10.1253/jcj.48.620
M3 - Article
C2 - 6088821
AN - SCOPUS:0021167028
SN - 0047-1828
VL - 48
SP - 620
EP - 632
JO - JAPANESE CIRCULATION JOURNAL
JF - JAPANESE CIRCULATION JOURNAL
IS - 7
ER -