The role of cyclophilin D in learning and memory

Akihiro Mouri, Yukihiro Noda, Shigeomi Shimizu, Yoshihide Tsujimoto, Toshitaka Nabeshima

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cyclophilin D (Cyp D) is implicated in cell death pathway and blockade of Cyp D could be a potent therapeutic strategy for degenerative disorders such as Alzheimer's disease, ischemia, and multiple sclerosis, but physiological role of Cyp D remains elusive. Here, we investigated the ability of learning and memory in several behavioral tasks in mice that lacked Cyp D (Cyp D-/-) and the relationship between ability of learning and memory and hippocampal architecture or neuronal transmission in Cyp D-/- mice. Cyp D -/- mice showed impairments of short-term memory in the Y-maze, object recognition memory in the novel-object recognition test, reference memory in the water maze test, and associative learning in the conditioned fear learning test. Hippocampal infusion of Cyclosporine A, which binds to Cyp D, replicated the defect in hippocampus-dependent cognition observed in Cyp D -/- mice. The Cyp D-/- mice did not show histopathological abnormalities upon Nissl staining and GFAP immunostaining or irregular expression of neuronal and glial marker proteins on Western blotting. However, release of glutamate and acetylcholine was decreased from the hippocampus in response to high-potassium treatment in the Cyp D-/- mice than in the wild-type mice. These results suggest a physiological role for Cyp D in learning and memory via the regulation of neurotransmission.

Original languageEnglish
Pages (from-to)293-304
Number of pages12
JournalHippocampus
Volume20
Issue number2
DOIs
Publication statusPublished - 01-02-2010

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Learning
Aptitude
Hippocampus
cyclophilin D
Short-Term Memory
Synaptic Transmission
Neuroglia
Cognition
Cyclosporine
Acetylcholine
Multiple Sclerosis
Fear
Glutamic Acid
Potassium
Alzheimer Disease
Cell Death
Ischemia
Western Blotting
Staining and Labeling
Water

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience

Cite this

Mouri, Akihiro ; Noda, Yukihiro ; Shimizu, Shigeomi ; Tsujimoto, Yoshihide ; Nabeshima, Toshitaka. / The role of cyclophilin D in learning and memory. In: Hippocampus. 2010 ; Vol. 20, No. 2. pp. 293-304.
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The role of cyclophilin D in learning and memory. / Mouri, Akihiro; Noda, Yukihiro; Shimizu, Shigeomi; Tsujimoto, Yoshihide; Nabeshima, Toshitaka.

In: Hippocampus, Vol. 20, No. 2, 01.02.2010, p. 293-304.

Research output: Contribution to journalArticle

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