TY - JOUR
T1 - The role of macrophages in bioartificial nerve grafts based on resorbable guiding filament structures
AU - Terada, N.
AU - Bjursten, L. M.
AU - Lundborg, G.
N1 - Funding Information:
This study was supported by grants form Swedish Medical Research Council (MFR, project 5188), Swedish Council for Work Life Research and Swedish National Board for Technical Development (NUTEK).
PY - 1997
Y1 - 1997
N2 - A 10 mm gap in a rat sciatic nerve was bridged by a bioartificial nerve graft consisting of a silicone tube containing seven longitudinally placed filaments made of non-resorbable material (polyamide [Ethilon®]) or resorbable materials (polydioxanon [PDS®], polyglactin [Vicryl®] or catgut). The purpose was to study the-tissue reaction induced by the four different types of materials. At 4 weeks an immunocytochemical technique, using ED1 and ED2 monoclonal antibodies, was used to study the presence and location of macrophages. A large number of macrophages were found accumulating on the surface of catgut and polyglactin, while few were found on the surface of polyamide and polydioxanon filaments. It is concluded that the cell layers on the filament surface mainly consisted of ED1 positive cells and their thickness depends on the filament materials.
AB - A 10 mm gap in a rat sciatic nerve was bridged by a bioartificial nerve graft consisting of a silicone tube containing seven longitudinally placed filaments made of non-resorbable material (polyamide [Ethilon®]) or resorbable materials (polydioxanon [PDS®], polyglactin [Vicryl®] or catgut). The purpose was to study the-tissue reaction induced by the four different types of materials. At 4 weeks an immunocytochemical technique, using ED1 and ED2 monoclonal antibodies, was used to study the presence and location of macrophages. A large number of macrophages were found accumulating on the surface of catgut and polyglactin, while few were found on the surface of polyamide and polydioxanon filaments. It is concluded that the cell layers on the filament surface mainly consisted of ED1 positive cells and their thickness depends on the filament materials.
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U2 - 10.1023/A:1018593219113
DO - 10.1023/A:1018593219113
M3 - Article
C2 - 15348742
AN - SCOPUS:0031172473
SN - 0957-4530
VL - 8
SP - 391
EP - 394
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 6
ER -