The role of mannan-binding lectin (MBL) gene polymorphism in ulcerative colitis

Fang Yu Wang, Tomiyasu Arisawa, Tomomitsu Tahara, Mitsuo Nagasaka, Hiroshi Fujita, Ichiro Hirata, Hiroshi Nakano

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Series studies suggest that enteropathogenic microorganisms play a substantial role in the clinical initiation and relapses of ulcerative colitis (UC). Mannan-binding lectin (MBL) is an important constituent of the innate immune system, and deficiency of MBL has been reported to increase the overall susceptibility of an individual to infectious disease. This study was aimed to investigate the associations between polymorphisms of the MBL gene and UC. Recruited in this study were 108 Japanese patients with UC and 144 healthy control subjects. Polymorphism at codon 54 of exon 1 of the MBL gene was investigated by polymerase chain reaction based restriction fragment length polymorphism. In general, no significant difference in MBL polymorphism was found between UC patients and health controls. However, the frequency of A carriers was significantly higher in the relapsing cases than controls (Odds ration = 2.19, 95%CI, 1.10-4.34; p = 0.023), and similar tendency was also found in A/A genotype. In conclusion, the polymorphism at codon 54 of exon 1 of the MBL gene associated with the susceptibility to the relapsing phenotype of ulcerative colitis. It suggests that codon 54 A variants of MBL gene may have an increased risk for the flare-ups of UC.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalJournal of Clinical Biochemistry and Nutrition
Volume42
Issue number1
DOIs
Publication statusPublished - 01-2008

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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