The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells

Kazuko Miyazaki, Masaki Miyazaki, Yun Guo, Norimasa Yamasaki, Masamoto Kanno, Zen Ichiro Honda, Hideaki Oda, Hiroshi Kawamoto, Hiroaki Honda

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Naturally occurring regulatory T (Treg) cells play a central role in the maintenance of immune homeostasis and in restraining the development of spontaneous inflammatory responses. However, the underlying mechanisms of Treg homeostasis remain incompletely understood. Of particular note, the IL-2Rα (CD25) is crucial for the homeostasis of Treg cells and the prevention of lymphoproliferative autoimmune disease. In this paper, we report that the basic helix-loop-helix transcription factor Dec1 is involved in the homeostasis of Treg cells and plays a role in their survival or expansion after adoptive transfer to lymphopenic recipients. Hence, it is crucial for the suppression of effector T cell-mediated inflammatory responses. Enforced expression of Dec1 upregulates CD25 expression during thymocyte development and increases the number of Treg cells in the periphery. Dec1 binds the transcription factor Runx1 and colocalizes with Runx1 in Treg cells. Specifically, we demonstrate that in Treg cells the Dec1/Runx1 complex binds to regulatory elements present in the Il-2ra locus. Collectively, these data show how Dec1 mechanistically acts in Treg cells.

Original languageEnglish
Pages (from-to)7330-7339
Number of pages10
JournalJournal of Immunology
Volume185
Issue number12
DOIs
Publication statusPublished - 15-12-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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