The Role of the Habenula in Depression: A Review of the Human fMRI Studies

Atsuo Yoshino, Hidenori Aizawa, Masahiro Takamura, Naho Ichikawa, Chiyo Shibasaki, Yosuke Yamawaki, Takafumi Sasaoka, Yasumasa Okamoto, Shigeto Yamawaki

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Depression has various symptoms, such as depressed mood or loss of motivation, and the pathophysiological mechanisms remain unclear. Recent studies have increased the understanding of the role of the habenula, since the habenula is reported to control the metabolism of monoamine neurotransmitters in the brain through direct projections to the ventral tegmental area and raphe nucleus. Human neuroimaging studies have been performed to attempt to clarify the mechanisms of depression. This manuscript mainly introduces human neuroimaging studies of the role of the habenula in depression.

Original languageEnglish
Pages (from-to)1017-1023
Number of pages7
JournalBrain and nerve = Shinkei kenkyu no shinpo
Volume70
Issue number9
DOIs
Publication statusPublished - 01-09-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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