TY - JOUR
T1 - The Role of the Habenula in Depression
T2 - A Review of the Human fMRI Studies
AU - Yoshino, Atsuo
AU - Aizawa, Hidenori
AU - Takamura, Masahiro
AU - Ichikawa, Naho
AU - Shibasaki, Chiyo
AU - Yamawaki, Yosuke
AU - Sasaoka, Takafumi
AU - Okamoto, Yasumasa
AU - Yamawaki, Shigeto
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Depression has various symptoms, such as depressed mood or loss of motivation, and the pathophysiological mechanisms remain unclear. Recent studies have increased the understanding of the role of the habenula, since the habenula is reported to control the metabolism of monoamine neurotransmitters in the brain through direct projections to the ventral tegmental area and raphe nucleus. Human neuroimaging studies have been performed to attempt to clarify the mechanisms of depression. This manuscript mainly introduces human neuroimaging studies of the role of the habenula in depression.
AB - Depression has various symptoms, such as depressed mood or loss of motivation, and the pathophysiological mechanisms remain unclear. Recent studies have increased the understanding of the role of the habenula, since the habenula is reported to control the metabolism of monoamine neurotransmitters in the brain through direct projections to the ventral tegmental area and raphe nucleus. Human neuroimaging studies have been performed to attempt to clarify the mechanisms of depression. This manuscript mainly introduces human neuroimaging studies of the role of the habenula in depression.
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U2 - 10.11477/mf.1416201121
DO - 10.11477/mf.1416201121
M3 - Review article
C2 - 30177579
AN - SCOPUS:85055081011
SN - 1881-6096
VL - 70
SP - 1017
EP - 1023
JO - Brain and nerve = Shinkei kenkyu no shinpo
JF - Brain and nerve = Shinkei kenkyu no shinpo
IS - 9
ER -