The role of tissue plasminogen activator in methamphetamine-related reward and sensitization

Taku Nagai, Yukihiro Noda, Kazuhiro Ishikawa, Yoshiaki Miyamoto, Masako Yoshimura, Mina Ito, Masanori Takayanagi, Kazuhiro Takuma, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

In the central nervous system, tissue plasminogen activator (tPA) plays a role in synaptic plasticity and remodeling. Our recent study has suggested that tPA participates in the rewarding effects of morphine by regulating dopamine release. In this study, we investigated the role of tPA in methamphetamine (METH)-related reward and sensitization. Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas. The METH-induced increase in tPA mRNA expression in the nucleus accumbens was completely inhibited by pre-treatment with R(+)-SCH23390 and raclopride, dopamine D1 and D2 receptor antagonists, respectively. In addition, repeated METH treatment increased tPA activity in the nucleus accumbens. There was no difference in METH-induced hyperlocomotion between wild-type and tPA-deficient (tPA-/-) mice. On the other hand, METH-induced conditioned place preference and behavioral sensitization after repeated METH treatment were significantly reduced in tPA-/- mice compared with wild-type mice. The defect of behavioral sensitization in tPA-/- mice was reversed by microinjections of exogenous tPA into the nucleus accumbens. Our findings suggest that tPA is involved in the rewarding effects as well as the sensitization of the locomotor-stimulating effect of METH.

Original languageEnglish
Pages (from-to)660-667
Number of pages8
JournalJournal of Neurochemistry
Volume92
Issue number3
DOIs
Publication statusPublished - 01-02-2005
Externally publishedYes

Fingerprint

Methamphetamine
Tissue Plasminogen Activator
Reward
Nucleus Accumbens
Messenger RNA
Raclopride
Therapeutics
Dopamine D1 Receptors
Neuronal Plasticity
Dopamine D2 Receptors
Microinjections
Neurology
Frontal Lobe
Morphine
Plasticity
Hippocampus
Dopamine
Brain
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Nagai, Taku ; Noda, Yukihiro ; Ishikawa, Kazuhiro ; Miyamoto, Yoshiaki ; Yoshimura, Masako ; Ito, Mina ; Takayanagi, Masanori ; Takuma, Kazuhiro ; Yamada, Kiyofumi ; Nabeshima, Toshitaka. / The role of tissue plasminogen activator in methamphetamine-related reward and sensitization. In: Journal of Neurochemistry. 2005 ; Vol. 92, No. 3. pp. 660-667.
@article{df26d1f8bc0a4967b73f6e0bd735a841,
title = "The role of tissue plasminogen activator in methamphetamine-related reward and sensitization",
abstract = "In the central nervous system, tissue plasminogen activator (tPA) plays a role in synaptic plasticity and remodeling. Our recent study has suggested that tPA participates in the rewarding effects of morphine by regulating dopamine release. In this study, we investigated the role of tPA in methamphetamine (METH)-related reward and sensitization. Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas. The METH-induced increase in tPA mRNA expression in the nucleus accumbens was completely inhibited by pre-treatment with R(+)-SCH23390 and raclopride, dopamine D1 and D2 receptor antagonists, respectively. In addition, repeated METH treatment increased tPA activity in the nucleus accumbens. There was no difference in METH-induced hyperlocomotion between wild-type and tPA-deficient (tPA-/-) mice. On the other hand, METH-induced conditioned place preference and behavioral sensitization after repeated METH treatment were significantly reduced in tPA-/- mice compared with wild-type mice. The defect of behavioral sensitization in tPA-/- mice was reversed by microinjections of exogenous tPA into the nucleus accumbens. Our findings suggest that tPA is involved in the rewarding effects as well as the sensitization of the locomotor-stimulating effect of METH.",
author = "Taku Nagai and Yukihiro Noda and Kazuhiro Ishikawa and Yoshiaki Miyamoto and Masako Yoshimura and Mina Ito and Masanori Takayanagi and Kazuhiro Takuma and Kiyofumi Yamada and Toshitaka Nabeshima",
year = "2005",
month = "2",
day = "1",
doi = "10.1111/j.1471-4159.2004.02903.x",
language = "English",
volume = "92",
pages = "660--667",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "3",

}

Nagai, T, Noda, Y, Ishikawa, K, Miyamoto, Y, Yoshimura, M, Ito, M, Takayanagi, M, Takuma, K, Yamada, K & Nabeshima, T 2005, 'The role of tissue plasminogen activator in methamphetamine-related reward and sensitization', Journal of Neurochemistry, vol. 92, no. 3, pp. 660-667. https://doi.org/10.1111/j.1471-4159.2004.02903.x

The role of tissue plasminogen activator in methamphetamine-related reward and sensitization. / Nagai, Taku; Noda, Yukihiro; Ishikawa, Kazuhiro; Miyamoto, Yoshiaki; Yoshimura, Masako; Ito, Mina; Takayanagi, Masanori; Takuma, Kazuhiro; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Journal of Neurochemistry, Vol. 92, No. 3, 01.02.2005, p. 660-667.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The role of tissue plasminogen activator in methamphetamine-related reward and sensitization

AU - Nagai, Taku

AU - Noda, Yukihiro

AU - Ishikawa, Kazuhiro

AU - Miyamoto, Yoshiaki

AU - Yoshimura, Masako

AU - Ito, Mina

AU - Takayanagi, Masanori

AU - Takuma, Kazuhiro

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 2005/2/1

Y1 - 2005/2/1

N2 - In the central nervous system, tissue plasminogen activator (tPA) plays a role in synaptic plasticity and remodeling. Our recent study has suggested that tPA participates in the rewarding effects of morphine by regulating dopamine release. In this study, we investigated the role of tPA in methamphetamine (METH)-related reward and sensitization. Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas. The METH-induced increase in tPA mRNA expression in the nucleus accumbens was completely inhibited by pre-treatment with R(+)-SCH23390 and raclopride, dopamine D1 and D2 receptor antagonists, respectively. In addition, repeated METH treatment increased tPA activity in the nucleus accumbens. There was no difference in METH-induced hyperlocomotion between wild-type and tPA-deficient (tPA-/-) mice. On the other hand, METH-induced conditioned place preference and behavioral sensitization after repeated METH treatment were significantly reduced in tPA-/- mice compared with wild-type mice. The defect of behavioral sensitization in tPA-/- mice was reversed by microinjections of exogenous tPA into the nucleus accumbens. Our findings suggest that tPA is involved in the rewarding effects as well as the sensitization of the locomotor-stimulating effect of METH.

AB - In the central nervous system, tissue plasminogen activator (tPA) plays a role in synaptic plasticity and remodeling. Our recent study has suggested that tPA participates in the rewarding effects of morphine by regulating dopamine release. In this study, we investigated the role of tPA in methamphetamine (METH)-related reward and sensitization. Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas. The METH-induced increase in tPA mRNA expression in the nucleus accumbens was completely inhibited by pre-treatment with R(+)-SCH23390 and raclopride, dopamine D1 and D2 receptor antagonists, respectively. In addition, repeated METH treatment increased tPA activity in the nucleus accumbens. There was no difference in METH-induced hyperlocomotion between wild-type and tPA-deficient (tPA-/-) mice. On the other hand, METH-induced conditioned place preference and behavioral sensitization after repeated METH treatment were significantly reduced in tPA-/- mice compared with wild-type mice. The defect of behavioral sensitization in tPA-/- mice was reversed by microinjections of exogenous tPA into the nucleus accumbens. Our findings suggest that tPA is involved in the rewarding effects as well as the sensitization of the locomotor-stimulating effect of METH.

UR - http://www.scopus.com/inward/record.url?scp=19944434191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944434191&partnerID=8YFLogxK

U2 - 10.1111/j.1471-4159.2004.02903.x

DO - 10.1111/j.1471-4159.2004.02903.x

M3 - Article

C2 - 15659235

AN - SCOPUS:19944434191

VL - 92

SP - 660

EP - 667

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 3

ER -