The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Courtney L. Luterbach; Ashley Boshe; Heather I. Henderson; Eric Cober; Sandra S. Richter; Robert A. Salata; Robert C. Kalayjian; Richard R. Watkins; Andrea M. Hujer; Kristine M. Hujer; Susan D. Rudin; T. Nicholas Domitrovic; Yohei Doi; Keith S. Kaye; Scott Evans; Vance G. Fowler; Robert A. Bonomo; David Van Duin

doi:10.1093/ofid/ofy351

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Courtney L. Luterbach, Ashley Boshe, Heather I. Henderson, Eric Cober, Sandra S. Richter, Robert A. Salata, Robert C. Kalayjian, Richard R. Watkins, Andrea M. Hujer, Kristine M. Hujer, Susan D. Rudin, T. Nicholas Domitrovic, Yohei Doi, Keith S. Kaye, Scott Evans, Vance G. Fowler, Robert A. Bonomo, David Van Duin

Department of Microbiology

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMPSMX. Development of resistance further limits the use of TMPSMX in CRE infections.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofy351
Publication status	Published - 01-01-2019

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All Science Journal Classification (ASJC) codes

Oncology
Clinical Neurology

Cite this

Luterbach, C. L., Boshe, A., Henderson, H. I., Cober, E., Richter, S. S., Salata, R. A., Kalayjian, R. C., Watkins, R. R., Hujer, A. M., Hujer, K. M., Rudin, S. D., Domitrovic, T. N., Doi, Y., Kaye, K. S., Evans, S., Fowler, V. G., Bonomo, R. A., & Van Duin, D. (2019). The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae. Open Forum Infectious Diseases, 6(1). https://doi.org/10.1093/ofid/ofy351

Luterbach, Courtney L. ; Boshe, Ashley ; Henderson, Heather I. ; Cober, Eric ; Richter, Sandra S. ; Salata, Robert A. ; Kalayjian, Robert C. ; Watkins, Richard R. ; Hujer, Andrea M. ; Hujer, Kristine M. ; Rudin, Susan D. ; Domitrovic, T. Nicholas ; Doi, Yohei ; Kaye, Keith S. ; Evans, Scott ; Fowler, Vance G. ; Bonomo, Robert A. ; Van Duin, David. / The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae. In: Open Forum Infectious Diseases. 2019 ; Vol. 6, No. 1.

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abstract = "In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMPSMX. Development of resistance further limits the use of TMPSMX in CRE infections.",

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Luterbach, CL, Boshe, A, Henderson, HI, Cober, E, Richter, SS, Salata, RA, Kalayjian, RC, Watkins, RR, Hujer, AM, Hujer, KM, Rudin, SD, Domitrovic, TN, Doi, Y, Kaye, KS, Evans, S, Fowler, VG, Bonomo, RA & Van Duin, D 2019, 'The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae', Open Forum Infectious Diseases, vol. 6, no. 1. https://doi.org/10.1093/ofid/ofy351

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae. / Luterbach, Courtney L.; Boshe, Ashley; Henderson, Heather I.; Cober, Eric; Richter, Sandra S.; Salata, Robert A.; Kalayjian, Robert C.; Watkins, Richard R.; Hujer, Andrea M.; Hujer, Kristine M.; Rudin, Susan D.; Domitrovic, T. Nicholas; Doi, Yohei; Kaye, Keith S.; Evans, Scott; Fowler, Vance G.; Bonomo, Robert A.; Van Duin, David.

In: Open Forum Infectious Diseases, Vol. 6, No. 1, 01.01.2019.

Research output: Contribution to journal › Article

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Access to Document

10.1093/ofid/ofy351