The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Courtney L. Luterbach, Ashley Boshe, Heather I. Henderson, Eric Cober, Sandra S. Richter, Robert A. Salata, Robert C. Kalayjian, Richard R. Watkins, Andrea M. Hujer, Kristine M. Hujer, Susan D. Rudin, T. Nicholas Domitrovic, Yohei Doi, Keith S. Kaye, Scott Evans, Vance G. Fowler, Robert A. Bonomo, David Van Duin

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Abstract

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMPSMX. Development of resistance further limits the use of TMPSMX in CRE infections.

Original languageEnglish
JournalOpen Forum Infectious Diseases
Volume6
Issue number1
DOIs
Publication statusPublished - 01-01-2019

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology

Cite this

Luterbach, C. L., Boshe, A., Henderson, H. I., Cober, E., Richter, S. S., Salata, R. A., Kalayjian, R. C., Watkins, R. R., Hujer, A. M., Hujer, K. M., Rudin, S. D., Domitrovic, T. N., Doi, Y., Kaye, K. S., Evans, S., Fowler, V. G., Bonomo, R. A., & Van Duin, D. (2019). The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae. Open Forum Infectious Diseases, 6(1). https://doi.org/10.1093/ofid/ofy351