The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Courtney L. Luterbach; Ashley Boshe; Heather I. Henderson; Eric Cober; Sandra S. Richter; Robert A. Salata; Robert C. Kalayjian; Richard R. Watkins; Andrea M. Hujer; Kristine M. Hujer; Susan D. Rudin; T. Nicholas Domitrovic; Yohei Doi; Keith S. Kaye; Scott Evans; Vance G. Fowler; Robert A. Bonomo; David Van Duin

doi:10.1093/ofid/ofy351

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Courtney L. Luterbach
, Ashley Boshe
, Heather I. Henderson
, Eric Cober
, Sandra S. Richter
, Robert A. Salata
, Robert C. Kalayjian
, Richard R. Watkins
, Andrea M. Hujer
, Kristine M. Hujer
, Susan D. Rudin
, T. Nicholas Domitrovic
, Yohei Doi
, Keith S. Kaye
, Scott Evans
, Vance G. Fowler
, Robert A. Bonomo
, David Van Duin

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMPSMX. Development of resistance further limits the use of TMPSMX in CRE infections.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofy351
Publication status	Published - 01-01-2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Infectious Diseases

Access to Document

10.1093/ofid/ofy351

Cite this

Luterbach, C. L., Boshe, A., Henderson, H. I., Cober, E., Richter, S. S., Salata, R. A., Kalayjian, R. C., Watkins, R. R., Hujer, A. M., Hujer, K. M., Rudin, S. D., Domitrovic, T. N., Doi, Y., Kaye, K. S., Evans, S., Fowler, V. G., Bonomo, R. A., & Van Duin, D. (2019). The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae. Open Forum Infectious Diseases, 6(1). https://doi.org/10.1093/ofid/ofy351

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title = "The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae",

abstract = "In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29\% were susceptible to TMPSMX. Development of resistance further limits the use of TMPSMX in CRE infections.",

keywords = "Klebsiella pneumonia, antimicrobial resistance, carbapenem-resistant Enterobacteriaceae, trimethoprim-sulfamethoxazole, urinary tract infection",

author = "Luterbach, \{Courtney L.\} and Ashley Boshe and Henderson, \{Heather I.\} and Eric Cober and Richter, \{Sandra S.\} and Salata, \{Robert A.\} and Kalayjian, \{Robert C.\} and Watkins, \{Richard R.\} and Hujer, \{Andrea M.\} and Hujer, \{Kristine M.\} and Rudin, \{Susan D.\} and Domitrovic, \{T. Nicholas\} and Yohei Doi and Kaye, \{Keith S.\} and Scott Evans and Fowler, \{Vance G.\} and Bonomo, \{Robert A.\} and \{Van Duin\}, David",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018.",

year = "2019",

month = jan,

day = "1",

doi = "10.1093/ofid/ofy351",

language = "English",

volume = "6",

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Luterbach, CL, Boshe, A, Henderson, HI, Cober, E, Richter, SS, Salata, RA, Kalayjian, RC, Watkins, RR, Hujer, AM, Hujer, KM, Rudin, SD, Domitrovic, TN, Doi, Y, Kaye, KS, Evans, S, Fowler, VG, Bonomo, RA & Van Duin, D 2019, 'The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae', Open Forum Infectious Diseases, vol. 6, no. 1. https://doi.org/10.1093/ofid/ofy351

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T1 - The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

AU - Luterbach, Courtney L.

AU - Boshe, Ashley

AU - Henderson, Heather I.

AU - Cober, Eric

AU - Richter, Sandra S.

AU - Salata, Robert A.

AU - Kalayjian, Robert C.

AU - Watkins, Richard R.

AU - Hujer, Andrea M.

AU - Hujer, Kristine M.

AU - Rudin, Susan D.

AU - Domitrovic, T. Nicholas

AU - Doi, Yohei

AU - Kaye, Keith S.

AU - Evans, Scott

AU - Fowler, Vance G.

AU - Bonomo, Robert A.

AU - Van Duin, David

PY - 2019/1/1

Y1 - 2019/1/1

N2 - In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMPSMX. Development of resistance further limits the use of TMPSMX in CRE infections.

AB - In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMPSMX. Development of resistance further limits the use of TMPSMX in CRE infections.

KW - Klebsiella pneumonia

KW - antimicrobial resistance

KW - carbapenem-resistant Enterobacteriaceae

KW - trimethoprim-sulfamethoxazole

KW - urinary tract infection

UR - https://www.scopus.com/pages/publications/85062192046

UR - https://www.scopus.com/pages/publications/85062192046#tab=citedBy

U2 - 10.1093/ofid/ofy351

DO - 10.1093/ofid/ofy351

M3 - Article

AN - SCOPUS:85062192046

SN - 2328-8957

VL - 6

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 1

ER -

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Abstract

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