TY - JOUR
T1 - The roles of Polycomb group proteins in hematopoietic stem cells and hematological malignancies
AU - Takamatsu-Ichihara, Emi
AU - Kitabayashi, Issay
N1 - Publisher Copyright:
© 2016, The Japanese Society of Hematology.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Polycomb group (PcG) proteins are epigenetic regulatory factors that maintain the repression of target gene expression through histone modification. PcG proteins control the repression of genes that regulate differentiation and the cell cycle in the maintenance of hematopoietic stem cells (HSC). Moreover, abnormalities in expression level and mutations in PcG genes have been reported in various types of cancer, including hematological malignancies. In this review, we present an overview of the roles of PcG proteins in HSC and various types of hematological malignancies.
AB - Polycomb group (PcG) proteins are epigenetic regulatory factors that maintain the repression of target gene expression through histone modification. PcG proteins control the repression of genes that regulate differentiation and the cell cycle in the maintenance of hematopoietic stem cells (HSC). Moreover, abnormalities in expression level and mutations in PcG genes have been reported in various types of cancer, including hematological malignancies. In this review, we present an overview of the roles of PcG proteins in HSC and various types of hematological malignancies.
UR - https://www.scopus.com/pages/publications/84963735748
UR - https://www.scopus.com/pages/publications/84963735748#tab=citedBy
U2 - 10.1007/s12185-016-2011-5
DO - 10.1007/s12185-016-2011-5
M3 - Review article
C2 - 27086351
AN - SCOPUS:84963735748
SN - 0925-5710
VL - 103
SP - 634
EP - 642
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 6
ER -
