TY - JOUR
T1 - The schizophrenia genetics knowledgebase
T2 - a comprehensive update of findings from candidate gene studies
AU - Liu, Chenxing
AU - Kanazawa, Tetsufumi
AU - Tian, Ye
AU - Mohamed Saini, Suriati
AU - Mancuso, Serafino
AU - Mostaid, Md Shaki
AU - Takahashi, Atsushi
AU - Zhang, Dai
AU - Zhang, Fuquan
AU - Yu, Hao
AU - Doo Shin, Hyoung
AU - Sub Cheong, Hyun
AU - Ikeda, Masashi
AU - Kubo, Michiaki
AU - Iwata, Nakao
AU - Woo, Sung Il
AU - Yue, Weihua
AU - Kamatani, Yoichiro
AU - Shi, Yongyong
AU - Li, Zhiqiang
AU - Everall, Ian
AU - Pantelis, Christos
AU - Bousman, Chad
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies’ findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community.
AB - Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies’ findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community.
UR - https://www.scopus.com/pages/publications/85071309317
UR - https://www.scopus.com/pages/publications/85071309317#tab=citedBy
U2 - 10.1038/s41398-019-0532-4
DO - 10.1038/s41398-019-0532-4
M3 - Article
C2 - 31455759
AN - SCOPUS:85071309317
SN - 2158-3188
VL - 9
JO - Translational psychiatry
JF - Translational psychiatry
IS - 1
M1 - 205
ER -
