The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013

Ryoichi Hamasuna; Mitsuru Yasuda; Kiyohito Ishikawa; Shinya Uehara; Hiroshi Hayami; Satoshi Takahashi; Tetsuro Matsumoto; Shingo Yamamoto; Shinichi Minamitani; Akira Watanabe; Satoshi Iwata; Mitsuo Kaku; Junichi Kadota; Keisuke Sunakawa; Junko Sato; Hideaki Hanaki; Taiji Tsukamoto; Hiroshi Kiyota; Shin Egawa; Kazushi Tanaka; Soichi Arakawa; Masato Fujisawa; Hiromi Kumon; Kanao Kobayashi; Akio Matsubara; Seiji Naito; Kentaro Kuroiwa; Hideo Hirayama; Harunori Narita; Takahide Hosobe; Shin Ito; Kenji Ito; Shuichi Kawai; Masayasu Ito; Hirofumi Chokyu; Masaru Matsumura; Masaru Yoshioka; Satoshi Uno; Koichi Monden; Kazuo Takayama; Shinichi Kaji; Motoshi Kawahara; Toru Sumii; Hitoshi Kadena; Takamasa Yamaguchi; Shinichi Maeda; Shohei Nishi; Hirofumi Nishimura; Takeshi Shirane; Mutsumasa Yoh; Kikuo Akiyama; Toshio Imai; Motonori Kano

doi:10.1016/j.jiac.2015.01.010

The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013

Ryoichi Hamasuna, Mitsuru Yasuda, Kiyohito Ishikawa, Shinya Uehara, Hiroshi Hayami, Satoshi Takahashi, Tetsuro Matsumoto, Shingo Yamamoto, Shinichi Minamitani, Akira Watanabe, Satoshi Iwata, Mitsuo Kaku, Junichi Kadota, Keisuke Sunakawa, Junko Sato, Hideaki Hanaki, Taiji Tsukamoto, Hiroshi Kiyota, Shin Egawa, Kazushi TanakaSoichi Arakawa, Masato Fujisawa, Hiromi Kumon, Kanao Kobayashi, Akio Matsubara, Seiji Naito, Kentaro Kuroiwa, Hideo Hirayama, Harunori Narita, Takahide Hosobe, Shin Ito, Kenji Ito, Shuichi Kawai, Masayasu Ito, Hirofumi Chokyu, Masaru Matsumura, Masaru Yoshioka, Satoshi Uno, Koichi Monden, Kazuo Takayama, Shinichi Kaji, Motoshi Kawahara, Toru Sumii, Hitoshi Kadena, Takamasa Yamaguchi, Shinichi Maeda, Shohei Nishi, Hirofumi Nishimura, Takeshi Shirane, Mutsumasa Yoh, Kikuo Akiyama, Toshio Imai, Motonori Kano

Quality and Safety in Healthcare

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Abstract

Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N.gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N.gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1μg/ml.

Original language	English
Pages (from-to)	340-345
Number of pages	6
Journal	Journal of Infection and Chemotherapy
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.jiac.2015.01.010
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2015.01.010

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Hamasuna, R., Yasuda, M., Ishikawa, K., Uehara, S., Hayami, H., Takahashi, S., Matsumoto, T., Yamamoto, S., Minamitani, S., Watanabe, A., Iwata, S., Kaku, M., Kadota, J., Sunakawa, K., Sato, J., Hanaki, H., Tsukamoto, T., Kiyota, H., Egawa, S., ... Kano, M. (2015). The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013. Journal of Infection and Chemotherapy, 21(5), 340-345. https://doi.org/10.1016/j.jiac.2015.01.010

@article{37106086ec294a6e8b2b326aacaf8fdd,

title = "The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013",

abstract = "Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N.gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N.gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1μg/ml.",

author = "Ryoichi Hamasuna and Mitsuru Yasuda and Kiyohito Ishikawa and Shinya Uehara and Hiroshi Hayami and Satoshi Takahashi and Tetsuro Matsumoto and Shingo Yamamoto and Shinichi Minamitani and Akira Watanabe and Satoshi Iwata and Mitsuo Kaku and Junichi Kadota and Keisuke Sunakawa and Junko Sato and Hideaki Hanaki and Taiji Tsukamoto and Hiroshi Kiyota and Shin Egawa and Kazushi Tanaka and Soichi Arakawa and Masato Fujisawa and Hiromi Kumon and Kanao Kobayashi and Akio Matsubara and Seiji Naito and Kentaro Kuroiwa and Hideo Hirayama and Harunori Narita and Takahide Hosobe and Shin Ito and Kenji Ito and Shuichi Kawai and Masayasu Ito and Hirofumi Chokyu and Masaru Matsumura and Masaru Yoshioka and Satoshi Uno and Koichi Monden and Kazuo Takayama and Shinichi Kaji and Motoshi Kawahara and Toru Sumii and Hitoshi Kadena and Takamasa Yamaguchi and Shinichi Maeda and Shohei Nishi and Hirofumi Nishimura and Takeshi Shirane and Mutsumasa Yoh and Kikuo Akiyama and Toshio Imai and Motonori Kano",

note = "Publisher Copyright: {\textcopyright} 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.",

year = "2015",

doi = "10.1016/j.jiac.2015.01.010",

language = "English",

volume = "21",

pages = "340--345",

journal = "Journal of Infection and Chemotherapy",

issn = "1341-321X",

publisher = "Elsevier BV",

number = "5",

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Hamasuna, R, Yasuda, M, Ishikawa, K, Uehara, S, Hayami, H, Takahashi, S, Matsumoto, T, Yamamoto, S, Minamitani, S, Watanabe, A, Iwata, S, Kaku, M, Kadota, J, Sunakawa, K, Sato, J, Hanaki, H, Tsukamoto, T, Kiyota, H, Egawa, S, Tanaka, K, Arakawa, S, Fujisawa, M, Kumon, H, Kobayashi, K, Matsubara, A, Naito, S, Kuroiwa, K, Hirayama, H, Narita, H, Hosobe, T, Ito, S, Ito, K, Kawai, S, Ito, M, Chokyu, H, Matsumura, M, Yoshioka, M, Uno, S, Monden, K, Takayama, K, Kaji, S, Kawahara, M, Sumii, T, Kadena, H, Yamaguchi, T, Maeda, S, Nishi, S, Nishimura, H, Shirane, T, Yoh, M, Akiyama, K, Imai, T & Kano, M 2015, 'The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013', Journal of Infection and Chemotherapy, vol. 21, no. 5, pp. 340-345. https://doi.org/10.1016/j.jiac.2015.01.010

TY - JOUR

T1 - The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013

AU - Hamasuna, Ryoichi

AU - Yasuda, Mitsuru

AU - Ishikawa, Kiyohito

AU - Uehara, Shinya

AU - Hayami, Hiroshi

AU - Takahashi, Satoshi

AU - Matsumoto, Tetsuro

AU - Yamamoto, Shingo

AU - Minamitani, Shinichi

AU - Watanabe, Akira

AU - Iwata, Satoshi

AU - Kaku, Mitsuo

AU - Kadota, Junichi

AU - Sunakawa, Keisuke

AU - Sato, Junko

AU - Hanaki, Hideaki

AU - Tsukamoto, Taiji

AU - Kiyota, Hiroshi

AU - Egawa, Shin

AU - Tanaka, Kazushi

AU - Arakawa, Soichi

AU - Fujisawa, Masato

AU - Kumon, Hiromi

AU - Kobayashi, Kanao

AU - Matsubara, Akio

AU - Naito, Seiji

AU - Kuroiwa, Kentaro

AU - Hirayama, Hideo

AU - Narita, Harunori

AU - Hosobe, Takahide

AU - Ito, Shin

AU - Ito, Kenji

AU - Kawai, Shuichi

AU - Ito, Masayasu

AU - Chokyu, Hirofumi

AU - Matsumura, Masaru

AU - Yoshioka, Masaru

AU - Uno, Satoshi

AU - Monden, Koichi

AU - Takayama, Kazuo

AU - Kaji, Shinichi

AU - Kawahara, Motoshi

AU - Sumii, Toru

AU - Kadena, Hitoshi

AU - Yamaguchi, Takamasa

AU - Maeda, Shinichi

AU - Nishi, Shohei

AU - Nishimura, Hirofumi

AU - Shirane, Takeshi

AU - Yoh, Mutsumasa

AU - Akiyama, Kikuo

AU - Imai, Toshio

AU - Kano, Motonori

PY - 2015

Y1 - 2015

N2 - Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N.gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N.gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1μg/ml.

AB - Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N.gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N.gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1μg/ml.

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U2 - 10.1016/j.jiac.2015.01.010

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C2 - 25727286

AN - SCOPUS:84933049453

SN - 1341-321X

VL - 21

SP - 340

EP - 345

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

IS - 5

ER -

The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013

Abstract

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