TY - JOUR
T1 - The serum pepsinogen test as a predictor of gastric cancer
T2 - The Hisayama study
AU - Oishi, Yoshinori
AU - Kiyohara, Yutaka
AU - Kubo, Michiaki
AU - Tanaka, Keiichi
AU - Tanizaki, Yumihiro
AU - Ninomiya, Toshiharu
AU - Doi, Yasufumi
AU - Shikata, Kentaro
AU - Yonemoto, Koji
AU - Shirota, Tomoko
AU - Matsumoto, Takayuki
AU - Iida, Mitsuo
N1 - Funding Information:
This study was supported in part by a Special Co-ordination Fund for Promoting Science and a Fund for Technology and Innovative Development Projects in the Life Sciences from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2006/4
Y1 - 2006/4
N2 - The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged ≥40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988-2002). Compared with that for the negative SPT group (26 men, 10 women), gastric cancer incidence increased significantly for both men (n = 17; age-adjusted hazard ratio = 4.56, 95% confidence interval: 2.42, 8.60) and women (n = 6; age-adjusted hazard ratio = 5.84, 95% confidence interval: 2.00, 17.11) in the strong-positive SPT group. It was also significantly higher in the positive SPT group for men (n = 23; age-adjusted hazard ratio = 3.91, 95% confidence interval: 2.23, 6.86). These associations did not attenuate even after adjustment for other comprehensive risk factors. Stratified analysis revealed significant associations between the SPT and development of intestinal-type gastric cancer as well as of cancer in both Helicobacter pylori-negative and -positive subjects. These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection.
AB - The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged ≥40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988-2002). Compared with that for the negative SPT group (26 men, 10 women), gastric cancer incidence increased significantly for both men (n = 17; age-adjusted hazard ratio = 4.56, 95% confidence interval: 2.42, 8.60) and women (n = 6; age-adjusted hazard ratio = 5.84, 95% confidence interval: 2.00, 17.11) in the strong-positive SPT group. It was also significantly higher in the positive SPT group for men (n = 23; age-adjusted hazard ratio = 3.91, 95% confidence interval: 2.23, 6.86). These associations did not attenuate even after adjustment for other comprehensive risk factors. Stratified analysis revealed significant associations between the SPT and development of intestinal-type gastric cancer as well as of cancer in both Helicobacter pylori-negative and -positive subjects. These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection.
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U2 - 10.1093/aje/kwj088
DO - 10.1093/aje/kwj088
M3 - Article
C2 - 16443800
AN - SCOPUS:33645306583
SN - 0002-9262
VL - 163
SP - 629
EP - 637
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 7
ER -