The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: The Hisayama Study

T. Saito, Y. Shimazaki, Y. Kiyohara, I. Kato, M. Kubo, M. Iida, T. Koga

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Inflammation is hypothesized to play a significant role in the development of type 2 diabetes; however, reports on clinical inflammatory conditions are limited. Studies have suggested that periodontitis affects glucose control in diabetics. This community-based study examined the relationship between periodontitis and glucose tolerance status, including changes in status. The relationship between periodontal condition and the results of a 75-g oral glucose tolerance test was examined in 961 adults in 1998. Deep pockets (mean pocket depth > 2.0 mm) were significantly associated with impaired glucose tolerance and with diabetes as compared with shallow pockets (< 1.3 mm). In the subgroup with normal glucose tolerance 10 years previously, subjects who subsequently developed impaired glucose tolerance were significantly more likely to have deep pockets. Deep pockets were closely related to current glucose tolerance status and the development of glucose intolerance.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
JournalJournal of Dental Research
Volume83
Issue number6
DOIs
Publication statusPublished - 06-2004

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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