TY - JOUR
T1 - The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics
T2 - The Hisayama Study
AU - Saito, T.
AU - Shimazaki, Y.
AU - Kiyohara, Y.
AU - Kato, I.
AU - Kubo, M.
AU - Iida, M.
AU - Koga, T.
N1 - Funding Information:
We thank Daisuke Ikeda, DDS, and Atsushi Hideshima, DDS, for periodontal examination. This work was supported by Grants-in-Aid of Scientific Research (No. 15390652 and 13670370) from the Ministry of Education, Science, Sports and Culture of Japan. This article is respectfully dedicated to the memory of Toshihiko Koga, who died on 14 October 2001.
PY - 2004/6
Y1 - 2004/6
N2 - Inflammation is hypothesized to play a significant role in the development of type 2 diabetes; however, reports on clinical inflammatory conditions are limited. Studies have suggested that periodontitis affects glucose control in diabetics. This community-based study examined the relationship between periodontitis and glucose tolerance status, including changes in status. The relationship between periodontal condition and the results of a 75-g oral glucose tolerance test was examined in 961 adults in 1998. Deep pockets (mean pocket depth > 2.0 mm) were significantly associated with impaired glucose tolerance and with diabetes as compared with shallow pockets (< 1.3 mm). In the subgroup with normal glucose tolerance 10 years previously, subjects who subsequently developed impaired glucose tolerance were significantly more likely to have deep pockets. Deep pockets were closely related to current glucose tolerance status and the development of glucose intolerance.
AB - Inflammation is hypothesized to play a significant role in the development of type 2 diabetes; however, reports on clinical inflammatory conditions are limited. Studies have suggested that periodontitis affects glucose control in diabetics. This community-based study examined the relationship between periodontitis and glucose tolerance status, including changes in status. The relationship between periodontal condition and the results of a 75-g oral glucose tolerance test was examined in 961 adults in 1998. Deep pockets (mean pocket depth > 2.0 mm) were significantly associated with impaired glucose tolerance and with diabetes as compared with shallow pockets (< 1.3 mm). In the subgroup with normal glucose tolerance 10 years previously, subjects who subsequently developed impaired glucose tolerance were significantly more likely to have deep pockets. Deep pockets were closely related to current glucose tolerance status and the development of glucose intolerance.
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U2 - 10.1177/154405910408300610
DO - 10.1177/154405910408300610
M3 - Article
C2 - 15153457
AN - SCOPUS:3042703072
SN - 0022-0345
VL - 83
SP - 485
EP - 490
JO - Journal of Dental Research
JF - Journal of Dental Research
IS - 6
ER -