The significance of molecular biomarkers on clinical survival outcome differs depending on colon cancer sidedness

Sho Hirabayashi; Masamichi Hayashi; Goro Nakayama; M. I.I. Shinji; Norifumi Hattori; Hiroshi Tanabe; Mitsuro Kanda; Chie Tanaka; Daisuke Kobayashi; Suguru Yamada; Masahiko Koike; Michitaka Fujiwara; Masahide Takahashi; Yasuhiro Kodera

doi:10.21873/anticanres.13941

The significance of molecular biomarkers on clinical survival outcome differs depending on colon cancer sidedness

Sho Hirabayashi, Masamichi Hayashi, Goro Nakayama, M. I.I. Shinji, Norifumi Hattori, Hiroshi Tanabe, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Suguru Yamada, Masahiko Koike, Michitaka Fujiwara, Masahide Takahashi, Yasuhiro Kodera

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background/Aim: This retrospective study focused on the correlation between molecular markers and prognostic outcomes of colon cancer patients depending on sidedness. Materials and Methods: A total of 117 stage I-III colon cancer patients who underwent colectomy were enrolled. Novel methylation markers (KIF1A, PAX5 and VGF) were selected for epigenetic evaluation and p53 and ERCC1 protein expression was examined for the investigation of genetic alterations. Results: High frequency of methylation was observed in 68.2% of right-sided and 39.7% of left-sided colon cancer cases (p=0.004). Abnormal p53 was identified in 52.3% of right-sided and 75.3% of left-sided cases (p=0.015). In right-sided cases, highly methylated genes demonstrated significantly favorable disease-free survival (p=0.049). Regarding left-sided cases, advanced T stage (p=0.028) and abnormal p53 (p=0.028) were revealed to be significant predictive factors of the disease-free survival outcome. Conclusion: Molecular alterations, as significant prognostic factors, might differ depending on the sidedness of colon cancers.

Original language	English
Pages (from-to)	201-211
Number of pages	11
Journal	Anticancer research
Volume	40
Issue number	1
DOIs	https://doi.org/10.21873/anticanres.13941
Publication status	Published - 2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.21873/anticanres.13941

Cite this

Hirabayashi, S., Hayashi, M., Nakayama, G., Shinji, M. I. I., Hattori, N., Tanabe, H., Kanda, M., Tanaka, C., Kobayashi, D., Yamada, S., Koike, M., Fujiwara, M., Takahashi, M., & Kodera, Y. (2020). The significance of molecular biomarkers on clinical survival outcome differs depending on colon cancer sidedness. Anticancer research, 40(1), 201-211. https://doi.org/10.21873/anticanres.13941

@article{7bc0e245383f47869bb9feaf62c0b5bd,

title = "The significance of molecular biomarkers on clinical survival outcome differs depending on colon cancer sidedness",

abstract = "Background/Aim: This retrospective study focused on the correlation between molecular markers and prognostic outcomes of colon cancer patients depending on sidedness. Materials and Methods: A total of 117 stage I-III colon cancer patients who underwent colectomy were enrolled. Novel methylation markers (KIF1A, PAX5 and VGF) were selected for epigenetic evaluation and p53 and ERCC1 protein expression was examined for the investigation of genetic alterations. Results: High frequency of methylation was observed in 68.2% of right-sided and 39.7% of left-sided colon cancer cases (p=0.004). Abnormal p53 was identified in 52.3% of right-sided and 75.3% of left-sided cases (p=0.015). In right-sided cases, highly methylated genes demonstrated significantly favorable disease-free survival (p=0.049). Regarding left-sided cases, advanced T stage (p=0.028) and abnormal p53 (p=0.028) were revealed to be significant predictive factors of the disease-free survival outcome. Conclusion: Molecular alterations, as significant prognostic factors, might differ depending on the sidedness of colon cancers.",

author = "Sho Hirabayashi and Masamichi Hayashi and Goro Nakayama and Shinji, {M. I.I.} and Norifumi Hattori and Hiroshi Tanabe and Mitsuro Kanda and Chie Tanaka and Daisuke Kobayashi and Suguru Yamada and Masahiko Koike and Michitaka Fujiwara and Masahide Takahashi and Yasuhiro Kodera",

year = "2020",

doi = "10.21873/anticanres.13941",

language = "English",

volume = "40",

pages = "201--211",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "1",

}

Hirabayashi, S, Hayashi, M, Nakayama, G, Shinji, MII, Hattori, N, Tanabe, H, Kanda, M, Tanaka, C, Kobayashi, D, Yamada, S, Koike, M, Fujiwara, M, Takahashi, M & Kodera, Y 2020, 'The significance of molecular biomarkers on clinical survival outcome differs depending on colon cancer sidedness', Anticancer research, vol. 40, no. 1, pp. 201-211. https://doi.org/10.21873/anticanres.13941

TY - JOUR

T1 - The significance of molecular biomarkers on clinical survival outcome differs depending on colon cancer sidedness

AU - Hirabayashi, Sho

AU - Hayashi, Masamichi

AU - Nakayama, Goro

AU - Shinji, M. I.I.

AU - Hattori, Norifumi

AU - Tanabe, Hiroshi

AU - Kanda, Mitsuro

AU - Tanaka, Chie

AU - Kobayashi, Daisuke

AU - Yamada, Suguru

AU - Koike, Masahiko

AU - Fujiwara, Michitaka

AU - Takahashi, Masahide

AU - Kodera, Yasuhiro

PY - 2020

Y1 - 2020

N2 - Background/Aim: This retrospective study focused on the correlation between molecular markers and prognostic outcomes of colon cancer patients depending on sidedness. Materials and Methods: A total of 117 stage I-III colon cancer patients who underwent colectomy were enrolled. Novel methylation markers (KIF1A, PAX5 and VGF) were selected for epigenetic evaluation and p53 and ERCC1 protein expression was examined for the investigation of genetic alterations. Results: High frequency of methylation was observed in 68.2% of right-sided and 39.7% of left-sided colon cancer cases (p=0.004). Abnormal p53 was identified in 52.3% of right-sided and 75.3% of left-sided cases (p=0.015). In right-sided cases, highly methylated genes demonstrated significantly favorable disease-free survival (p=0.049). Regarding left-sided cases, advanced T stage (p=0.028) and abnormal p53 (p=0.028) were revealed to be significant predictive factors of the disease-free survival outcome. Conclusion: Molecular alterations, as significant prognostic factors, might differ depending on the sidedness of colon cancers.

AB - Background/Aim: This retrospective study focused on the correlation between molecular markers and prognostic outcomes of colon cancer patients depending on sidedness. Materials and Methods: A total of 117 stage I-III colon cancer patients who underwent colectomy were enrolled. Novel methylation markers (KIF1A, PAX5 and VGF) were selected for epigenetic evaluation and p53 and ERCC1 protein expression was examined for the investigation of genetic alterations. Results: High frequency of methylation was observed in 68.2% of right-sided and 39.7% of left-sided colon cancer cases (p=0.004). Abnormal p53 was identified in 52.3% of right-sided and 75.3% of left-sided cases (p=0.015). In right-sided cases, highly methylated genes demonstrated significantly favorable disease-free survival (p=0.049). Regarding left-sided cases, advanced T stage (p=0.028) and abnormal p53 (p=0.028) were revealed to be significant predictive factors of the disease-free survival outcome. Conclusion: Molecular alterations, as significant prognostic factors, might differ depending on the sidedness of colon cancers.

UR - http://www.scopus.com/inward/record.url?scp=85077452897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077452897&partnerID=8YFLogxK

U2 - 10.21873/anticanres.13941

DO - 10.21873/anticanres.13941

M3 - Article

C2 - 31892568

AN - SCOPUS:85077452897

SN - 0250-7005

VL - 40

SP - 201

EP - 211

JO - Anticancer research

JF - Anticancer research

IS - 1

ER -

The significance of molecular biomarkers on clinical survival outcome differs depending on colon cancer sidedness

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this