The Skin Safety Evaluation of Pranoprofen•gel

Ritsuko Hayakawa, Kayoko Matsunaga, Chikako Ukei

Research output: Contribution to journalArticlepeer-review


We performed repeated open patch test, 48 hours closed patch test and photopatch test with 30 male healthy volunteers to evaluate the skin safety of Pranoprofen-gel which was developed as antiinflammatory and anodyne topical medicament. As controls of the tests, we took Indomethacin ointment and distilled water. The positive rates of pranoprofen � gel were significantly lower than those of Indomethacin ointment in repeated open patch test and 48 hours closed patch test. Pranoprofen-gel did not show positive reactions in photopatch test. Pranoprofen-gel was developed to be applied on the intact skin of the patients with, arthritis or sprain, so we decided that Pranoprofen-gel might be a safe topical medicament so far as being used correctly.

Original languageEnglish
Pages (from-to)1208-1217
Number of pages10
Journalskin research
Issue number6
Publication statusPublished - 01-01-1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases


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