TY - JOUR
T1 - The small SLC43 family
T2 - Facilitator system l amino acid transporters and the orphan EEG1
AU - Bodoy, Susanna
AU - Fotiadis, Dimitrios
AU - Stoeger, Claudia
AU - Kanai, Yoshikatsu
AU - Palacín, Manuel
PY - 2013/4
Y1 - 2013/4
N2 - The SLC43 family is composed of only three genes coding for the plasma membrane facilitator system l amino acid transporters LAT3 (SLC43A1; TC 2.A.1.44.1) and LAT4 (SLC43A2; TC 2.A.1.44.2), and the orphan protein EEG1 (SLC43A3; TC 2.A.1.44.3). Besides the known mechanism of transport of LAT3 and LAT4, their physiological roles still remain quite obscure. Morphants suggested a role of LAT3 in renal podocyte development in zebrafish. Expression in liver and skeletal muscle, and up-regulation by starvation suggest a role of LAT3 in the flux of branched-chain amino acids (BCAAs) from liver and skeletal muscle to the bloodstream. Finally, LAT3 is up-regulated in androgen-dependent cancers, suggesting a role in mTORC1 signaling in this type of tumors. In addition, LAT4 might contribute to the transfer of BCAAs from mother to fetus. Unfortunately, the EEG1 mouse model (EEG1Y221*) described here has not yet offered a clue to the physiological role of this orphan protein.
AB - The SLC43 family is composed of only three genes coding for the plasma membrane facilitator system l amino acid transporters LAT3 (SLC43A1; TC 2.A.1.44.1) and LAT4 (SLC43A2; TC 2.A.1.44.2), and the orphan protein EEG1 (SLC43A3; TC 2.A.1.44.3). Besides the known mechanism of transport of LAT3 and LAT4, their physiological roles still remain quite obscure. Morphants suggested a role of LAT3 in renal podocyte development in zebrafish. Expression in liver and skeletal muscle, and up-regulation by starvation suggest a role of LAT3 in the flux of branched-chain amino acids (BCAAs) from liver and skeletal muscle to the bloodstream. Finally, LAT3 is up-regulated in androgen-dependent cancers, suggesting a role in mTORC1 signaling in this type of tumors. In addition, LAT4 might contribute to the transfer of BCAAs from mother to fetus. Unfortunately, the EEG1 mouse model (EEG1Y221*) described here has not yet offered a clue to the physiological role of this orphan protein.
KW - EEG1
KW - l-type amino acid transporter
KW - LAT3
KW - LAT4
KW - SLC43
UR - https://www.scopus.com/pages/publications/84875142410
UR - https://www.scopus.com/pages/publications/84875142410#tab=citedBy
U2 - 10.1016/j.mam.2012.12.006
DO - 10.1016/j.mam.2012.12.006
M3 - Review article
C2 - 23268354
AN - SCOPUS:84875142410
SN - 0098-2997
VL - 34
SP - 638
EP - 645
JO - Molecular Aspects of Medicine
JF - Molecular Aspects of Medicine
IS - 2-3
ER -
