The spontaneous clearance of hepatitis E virus (HEV) and emergence of HEV antibodies in a transfusion-transmitted chronic hepatitis E case after completion of chemotherapy for acute myeloid leukemia

Hiroshi Okano, Tatsunori Nakano, Ryugo Ito, Ami Tanaka, Yuji Hoshi, Keiji Matsubayashi, Hiroki Asakawa, Kenji Nose, Satomi Tsuruga, Tomomasa Tochio, Hiroaki Kumazawa, Yoshiaki Isono, Hiroki Tanaka, Shimpei Matsusaki, Tomohiro Sase, Tomonori Saito, Katsumi Mukai, Akira Nishimura, Keiki Kawakami, Shigeo NagashimaMasaharu Takahashi, Hiroaki Okamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 64-year-old woman was infected with hepatitis E virus (HEV) during chemotherapy for leukemia. By retrospective analyses of stored serum from the blood products and the patient, the source of the infection was determined to be platelet concentration (PC) transfused during chemotherapy. The partial nucleotide sequence of the HEV strain isolated from the donated PC and that from the patient’s sera was identical and was subgenotype 3b. Clinical indicators such as alanine aminotransferase, HEV RNA titer, and anti-HEV antibodies in the serum were investigated from the beginning of the infection until 1 year after the termination of HEV infection. HEV RNA had propagated over 6 months and then cleared spontaneously after the completion of chemotherapy. Anti-HEV antibodies appeared in the serum just before the clearance of HEV RNA. Interestingly, HEV RNA was detected in the patient’s urine, spinal fluid, and saliva. The HEV RNA titers in those samples were much lower than in the serum and feces. No renal, neurological, or salivary gland disorders appeared during the follow-up. We observed virological and biochemical progress and cure of transfusion-transmitted chronic hepatitis E in the patient despite an immunosuppressive status during and after chemotherapy against hematological malignancy.

Original languageEnglish
Pages (from-to)252-259
Number of pages8
JournalClinical Journal of Gastroenterology
Volume13
Issue number2
DOIs
Publication statusPublished - 01-04-2020

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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    Okano, H., Nakano, T., Ito, R., Tanaka, A., Hoshi, Y., Matsubayashi, K., Asakawa, H., Nose, K., Tsuruga, S., Tochio, T., Kumazawa, H., Isono, Y., Tanaka, H., Matsusaki, S., Sase, T., Saito, T., Mukai, K., Nishimura, A., Kawakami, K., ... Okamoto, H. (2020). The spontaneous clearance of hepatitis E virus (HEV) and emergence of HEV antibodies in a transfusion-transmitted chronic hepatitis E case after completion of chemotherapy for acute myeloid leukemia. Clinical Journal of Gastroenterology, 13(2), 252-259. https://doi.org/10.1007/s12328-019-01024-3