The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery

Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Akira Yokoi, Takashi Inoue, Koji Suzuki, Yasuhiro Kusuhara, Nobuyuki Hamajima, Hiroji Takai, Tadayoshi Hata

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Abstract

Purpose: Assessment of plaque formation in the common carotid artery (CCA) is important for stratification of the risk of subsequent stroke. The stiffness parameter β, which can be assessed using an ultrasonic phase-locked echo-tracking system, was developed to evaluate arterial stiffness. The purpose this study was to examine the relationship of the stiffness parameter β to intima-media thickness (IMT) and plaque formation. Methods: The stiffness parameter β and mean IMT were measured using an ultrasonic phase-locked echo-tracking system and an automatic IMT measurement system, respectively, and the presence of plaque was assessed by ultrasonography in 347 subjects who took part in a health check-up program for community-dwelling people in Hokkaido. Results: Values of the stiffness parameter β were significantly higher in subjects with plaque formation than in those without plaque (10.60 ± 0.45 vs. 8.88 ± 0.23, P < 0.005) in whom IMT was not thickened; however, it was not different in subjects with increased IMT (>1.0 mm). The percentage of plaque formation was significantly correlated with the value of the stiffness parameter β. Furthermore, the stiffness parameter β was significantly correlated with plaque formation after adjustment for several clinical variables (odds ratio 1.113-1.178, P < 0.001). Conclusion: The stiffness parameter β is associated with plaque formation in the CCA, especially in subjects with a normal IMT. This could potentially be used as a predictor for plaque formation.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalJournal of Medical Ultrasonics
Volume39
Issue number1
DOIs
Publication statusPublished - 01-01-2012

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Common Carotid Artery
Ultrasonics
Independent Living
Vascular Stiffness
Ultrasonography
Stroke
Odds Ratio
Health

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery",
abstract = "Purpose: Assessment of plaque formation in the common carotid artery (CCA) is important for stratification of the risk of subsequent stroke. The stiffness parameter β, which can be assessed using an ultrasonic phase-locked echo-tracking system, was developed to evaluate arterial stiffness. The purpose this study was to examine the relationship of the stiffness parameter β to intima-media thickness (IMT) and plaque formation. Methods: The stiffness parameter β and mean IMT were measured using an ultrasonic phase-locked echo-tracking system and an automatic IMT measurement system, respectively, and the presence of plaque was assessed by ultrasonography in 347 subjects who took part in a health check-up program for community-dwelling people in Hokkaido. Results: Values of the stiffness parameter β were significantly higher in subjects with plaque formation than in those without plaque (10.60 ± 0.45 vs. 8.88 ± 0.23, P < 0.005) in whom IMT was not thickened; however, it was not different in subjects with increased IMT (>1.0 mm). The percentage of plaque formation was significantly correlated with the value of the stiffness parameter β. Furthermore, the stiffness parameter β was significantly correlated with plaque formation after adjustment for several clinical variables (odds ratio 1.113-1.178, P < 0.001). Conclusion: The stiffness parameter β is associated with plaque formation in the CCA, especially in subjects with a normal IMT. This could potentially be used as a predictor for plaque formation.",
author = "Naohiro Ichino and Keisuke Osakabe and Keiko Sugimoto and Akira Yokoi and Takashi Inoue and Koji Suzuki and Yasuhiro Kusuhara and Nobuyuki Hamajima and Hiroji Takai and Tadayoshi Hata",
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The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery. / Ichino, Naohiro; Osakabe, Keisuke; Sugimoto, Keiko; Yokoi, Akira; Inoue, Takashi; Suzuki, Koji; Kusuhara, Yasuhiro; Hamajima, Nobuyuki; Takai, Hiroji; Hata, Tadayoshi.

In: Journal of Medical Ultrasonics, Vol. 39, No. 1, 01.01.2012, p. 3-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery

AU - Ichino, Naohiro

AU - Osakabe, Keisuke

AU - Sugimoto, Keiko

AU - Yokoi, Akira

AU - Inoue, Takashi

AU - Suzuki, Koji

AU - Kusuhara, Yasuhiro

AU - Hamajima, Nobuyuki

AU - Takai, Hiroji

AU - Hata, Tadayoshi

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Purpose: Assessment of plaque formation in the common carotid artery (CCA) is important for stratification of the risk of subsequent stroke. The stiffness parameter β, which can be assessed using an ultrasonic phase-locked echo-tracking system, was developed to evaluate arterial stiffness. The purpose this study was to examine the relationship of the stiffness parameter β to intima-media thickness (IMT) and plaque formation. Methods: The stiffness parameter β and mean IMT were measured using an ultrasonic phase-locked echo-tracking system and an automatic IMT measurement system, respectively, and the presence of plaque was assessed by ultrasonography in 347 subjects who took part in a health check-up program for community-dwelling people in Hokkaido. Results: Values of the stiffness parameter β were significantly higher in subjects with plaque formation than in those without plaque (10.60 ± 0.45 vs. 8.88 ± 0.23, P < 0.005) in whom IMT was not thickened; however, it was not different in subjects with increased IMT (>1.0 mm). The percentage of plaque formation was significantly correlated with the value of the stiffness parameter β. Furthermore, the stiffness parameter β was significantly correlated with plaque formation after adjustment for several clinical variables (odds ratio 1.113-1.178, P < 0.001). Conclusion: The stiffness parameter β is associated with plaque formation in the CCA, especially in subjects with a normal IMT. This could potentially be used as a predictor for plaque formation.

AB - Purpose: Assessment of plaque formation in the common carotid artery (CCA) is important for stratification of the risk of subsequent stroke. The stiffness parameter β, which can be assessed using an ultrasonic phase-locked echo-tracking system, was developed to evaluate arterial stiffness. The purpose this study was to examine the relationship of the stiffness parameter β to intima-media thickness (IMT) and plaque formation. Methods: The stiffness parameter β and mean IMT were measured using an ultrasonic phase-locked echo-tracking system and an automatic IMT measurement system, respectively, and the presence of plaque was assessed by ultrasonography in 347 subjects who took part in a health check-up program for community-dwelling people in Hokkaido. Results: Values of the stiffness parameter β were significantly higher in subjects with plaque formation than in those without plaque (10.60 ± 0.45 vs. 8.88 ± 0.23, P < 0.005) in whom IMT was not thickened; however, it was not different in subjects with increased IMT (>1.0 mm). The percentage of plaque formation was significantly correlated with the value of the stiffness parameter β. Furthermore, the stiffness parameter β was significantly correlated with plaque formation after adjustment for several clinical variables (odds ratio 1.113-1.178, P < 0.001). Conclusion: The stiffness parameter β is associated with plaque formation in the CCA, especially in subjects with a normal IMT. This could potentially be used as a predictor for plaque formation.

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M3 - Article

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