TY - JOUR
T1 - The therapeutic effect of Lipo PGE1 on diabetic neuropathy-changes in endothelin and various angiopathic factors
AU - Itoh, Yasutoshi
AU - Yasui, Tadashi
AU - Kakizawa, Hiroaki
AU - Makino, Masaki
AU - Fujiwara, Kentaro
AU - Kato, Taiya
AU - Imamura, Shigeo
AU - Yamamoto, Keiko
AU - Hishida, Hitoshi
AU - Nakai, Akira
AU - Itoh, Mitusyasu
AU - Nagasaka, Akio
PY - 2001
Y1 - 2001
N2 - A high blood concentration of endothelin (ET)-1 may participate in the onset and progress of diabetic microangiopathy, resulting in neuropathy. We examined the therapeutic effects of prostaglandin E1 (PGE1), which possesses both a peripheral vasodilating action and inhibition of platelet aggregation, on diabetic microangiopathy. Increases in both skin temperature and peripheral never conduction velocity in diabetic patients were recorded four weeks after Lipo PGE1 administration. A quantitative decrease in urinary albumin concentration was also observed, suggesting its efficacy of action was on diabetic nephropathy. Lipo PGE1 administration reduced the elevated circulating plasma ET-1 levels in the diabetic patients. As an increase in ET-1 concentrations is thought to correlate with the onset and progress of diabetic microangiopathy, the reduction of plasma ET-1 concentration by Lipo PGE1 administration may be one reason for the improvement in diabetic neuropathy and nephropathy.
AB - A high blood concentration of endothelin (ET)-1 may participate in the onset and progress of diabetic microangiopathy, resulting in neuropathy. We examined the therapeutic effects of prostaglandin E1 (PGE1), which possesses both a peripheral vasodilating action and inhibition of platelet aggregation, on diabetic microangiopathy. Increases in both skin temperature and peripheral never conduction velocity in diabetic patients were recorded four weeks after Lipo PGE1 administration. A quantitative decrease in urinary albumin concentration was also observed, suggesting its efficacy of action was on diabetic nephropathy. Lipo PGE1 administration reduced the elevated circulating plasma ET-1 levels in the diabetic patients. As an increase in ET-1 concentrations is thought to correlate with the onset and progress of diabetic microangiopathy, the reduction of plasma ET-1 concentration by Lipo PGE1 administration may be one reason for the improvement in diabetic neuropathy and nephropathy.
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U2 - 10.1016/S0090-6980(01)00165-4
DO - 10.1016/S0090-6980(01)00165-4
M3 - Article
C2 - 11577785
AN - SCOPUS:0034837163
VL - 66
SP - 221
EP - 234
JO - Journal of Lipid Mediators
JF - Journal of Lipid Mediators
SN - 1098-8823
IS - 3
ER -