The third nationwide surveillance of antimicrobial susceptibility against Neisseria gonorrhoeae from male urethritis in Japan, 2016–2017

Mitsuru Yasuda; Satoshi Takahashi; Jun Miyazaki; Koichiro Wada; Kanao Kobayashi; Masahiro Matsumoto; Hiroshi Hayami; Shingo Yamamoto; Hiroshi Kiyota; Junko Sato; Tetsuya Matsumoto; Hiroshi Yotsuyanagi; Hideaki Hanaki; Naoya Masumori; Yoshiki Hiyama; Hiroyuki Nishiyama; Takahiro Kimura; Hiroki Yamada; Kazumasa Matsumoto; Kiyohito Ishikawa; Yoshikazu Togo; Kazushi Tanaka; Takuya Sadahira; Junichi Inokuchi; Ryoichi Hamasuna; Kenji Ito; Hideo Hirayama; Kenji Hayashi; Yuichiro Kurimura; Hitoshi Kadena; Shin Ito; Yutaka Shiono; Takahiro Maruyama; Masayasu Ito; Koichi Hatano; Hirofumi Chokyu; Hideari Ihara; Satoshi Uno; Koichi Monden; Teruhiko Yokoyama; Motonori Kano; Shinichi Kaji; Motoshi Kawahara; Toru Sumii; Takanori Tojo; Takahide Hosobe; Kazuhiko Naito; Shuichi Kawai; Hirofumi Nishimura; Masanobu Izumitani; Mutsumasa Yoh; Masaru Matsumura; Ryuji Fujita; Kazuo Takayama; Makoto Hara; Shohei Nishi

doi:10.1016/j.jiac.2023.08.003

The third nationwide surveillance of antimicrobial susceptibility against Neisseria gonorrhoeae from male urethritis in Japan, 2016–2017

Mitsuru Yasuda, Satoshi Takahashi, Jun Miyazaki, Koichiro Wada, Kanao Kobayashi, Masahiro Matsumoto, Hiroshi Hayami, Shingo Yamamoto, Hiroshi Kiyota, Junko Sato, Tetsuya Matsumoto, Hiroshi Yotsuyanagi, Hideaki Hanaki, Naoya Masumori, Yoshiki Hiyama, Hiroyuki Nishiyama, Takahiro Kimura, Hiroki Yamada, Kazumasa Matsumoto, Kiyohito IshikawaYoshikazu Togo, Kazushi Tanaka, Takuya Sadahira, Junichi Inokuchi, Ryoichi Hamasuna, Kenji Ito, Hideo Hirayama, Kenji Hayashi, Yuichiro Kurimura, Hitoshi Kadena, Shin Ito, Yutaka Shiono, Takahiro Maruyama, Masayasu Ito, Koichi Hatano, Hirofumi Chokyu, Hideari Ihara, Satoshi Uno, Koichi Monden, Teruhiko Yokoyama, Motonori Kano, Shinichi Kaji, Motoshi Kawahara, Toru Sumii, Takanori Tojo, Takahide Hosobe, Kazuhiko Naito, Shuichi Kawai, Hirofumi Nishimura, Masanobu Izumitani, Mutsumasa Yoh, Masaru Matsumura, Ryuji Fujita, Kazuo Takayama, Makoto Hara, Shohei Nishi

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Abstract

Neisseria gonorrhoeae is one of the important pathogens of sexually transmitted infections. N. gonorrhoeae is rapidly becoming antimicrobial resistant, and there are few drugs that are effective in the initial treatment of gonorrhea. To understand the trends of antimicrobial susceptibility of N. gonorrhoeae, the Surveillance Committee of the Japanese Society of Infectious Diseases, the Japanese Society for Chemotherapy, and the Japanese Society of Clinical Microbiology conducted the third nationwide antimicrobial susceptibility surveillance of N. gonorrhoeae isolated from male urethritis. The specimens were collected from male patients with urethritis at 30 facilities from May 2016 to July 2017. From the 159 specimens collected, 87 N. gonorrhoeae strains were isolated, and 85 were tested for susceptibility to 21 antimicrobial agents. All strains were non-susceptible to penicillin G. Seven strains (8.2%) were β-lactamase-producing strains. The rates of susceptibility to cefixime and cefpodoxime were 96.5% and 52.9%, respectively. Three strains were non-susceptible with a minimum inhibitory concentration (MIC) of 0.5 mg/L for cefixime. None of the strains were resistant to ceftriaxone or spectinomycin. The susceptibility rate for ciprofloxacin was 23.5% (20 strains), and no strains showed intermediate susceptibility. The susceptibility rate against azithromycin was 81.2%, with one strain isolated with a MIC of 8 mg/L against azithromycin. The results of this surveillance indicate that ceftriaxone and spectinomycin, which are currently recommended for gonococcal infections in Japan, appear to be effective. It will be necessary to further expand the scale of the next surveillance to understand the current status of drug-resistant N. gonorrhoeae in Japan.

Original language	English
Pages (from-to)	1011-1016
Number of pages	6
Journal	Journal of Infection and Chemotherapy
Volume	29
Issue number	11
DOIs	https://doi.org/10.1016/j.jiac.2023.08.003
Publication status	Published - 11-2023

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2023.08.003

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Yasuda, M., Takahashi, S., Miyazaki, J., Wada, K., Kobayashi, K., Matsumoto, M., Hayami, H., Yamamoto, S., Kiyota, H., Sato, J., Matsumoto, T., Yotsuyanagi, H., Hanaki, H., Masumori, N., Hiyama, Y., Nishiyama, H., Kimura, T., Yamada, H., Matsumoto, K., ... Nishi, S. (2023). The third nationwide surveillance of antimicrobial susceptibility against Neisseria gonorrhoeae from male urethritis in Japan, 2016–2017. Journal of Infection and Chemotherapy, 29(11), 1011-1016. https://doi.org/10.1016/j.jiac.2023.08.003

@article{d259c8eed98c46548cc8cf99e8521df2,

title = "The third nationwide surveillance of antimicrobial susceptibility against Neisseria gonorrhoeae from male urethritis in Japan, 2016–2017",

abstract = "Neisseria gonorrhoeae is one of the important pathogens of sexually transmitted infections. N. gonorrhoeae is rapidly becoming antimicrobial resistant, and there are few drugs that are effective in the initial treatment of gonorrhea. To understand the trends of antimicrobial susceptibility of N. gonorrhoeae, the Surveillance Committee of the Japanese Society of Infectious Diseases, the Japanese Society for Chemotherapy, and the Japanese Society of Clinical Microbiology conducted the third nationwide antimicrobial susceptibility surveillance of N. gonorrhoeae isolated from male urethritis. The specimens were collected from male patients with urethritis at 30 facilities from May 2016 to July 2017. From the 159 specimens collected, 87 N. gonorrhoeae strains were isolated, and 85 were tested for susceptibility to 21 antimicrobial agents. All strains were non-susceptible to penicillin G. Seven strains (8.2%) were β-lactamase-producing strains. The rates of susceptibility to cefixime and cefpodoxime were 96.5% and 52.9%, respectively. Three strains were non-susceptible with a minimum inhibitory concentration (MIC) of 0.5 mg/L for cefixime. None of the strains were resistant to ceftriaxone or spectinomycin. The susceptibility rate for ciprofloxacin was 23.5% (20 strains), and no strains showed intermediate susceptibility. The susceptibility rate against azithromycin was 81.2%, with one strain isolated with a MIC of 8 mg/L against azithromycin. The results of this surveillance indicate that ceftriaxone and spectinomycin, which are currently recommended for gonococcal infections in Japan, appear to be effective. It will be necessary to further expand the scale of the next surveillance to understand the current status of drug-resistant N. gonorrhoeae in Japan.",

author = "Mitsuru Yasuda and Satoshi Takahashi and Jun Miyazaki and Koichiro Wada and Kanao Kobayashi and Masahiro Matsumoto and Hiroshi Hayami and Shingo Yamamoto and Hiroshi Kiyota and Junko Sato and Tetsuya Matsumoto and Hiroshi Yotsuyanagi and Hideaki Hanaki and Naoya Masumori and Yoshiki Hiyama and Hiroyuki Nishiyama and Takahiro Kimura and Hiroki Yamada and Kazumasa Matsumoto and Kiyohito Ishikawa and Yoshikazu Togo and Kazushi Tanaka and Takuya Sadahira and Junichi Inokuchi and Ryoichi Hamasuna and Kenji Ito and Hideo Hirayama and Kenji Hayashi and Yuichiro Kurimura and Hitoshi Kadena and Shin Ito and Yutaka Shiono and Takahiro Maruyama and Masayasu Ito and Koichi Hatano and Hirofumi Chokyu and Hideari Ihara and Satoshi Uno and Koichi Monden and Teruhiko Yokoyama and Motonori Kano and Shinichi Kaji and Motoshi Kawahara and Toru Sumii and Takanori Tojo and Takahide Hosobe and Kazuhiko Naito and Shuichi Kawai and Hirofumi Nishimura and Masanobu Izumitani and Mutsumasa Yoh and Masaru Matsumura and Ryuji Fujita and Kazuo Takayama and Makoto Hara and Shohei Nishi",

note = "Publisher Copyright: {\textcopyright} 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control",

year = "2023",

month = nov,

doi = "10.1016/j.jiac.2023.08.003",

language = "English",

volume = "29",

pages = "1011--1016",

journal = "Journal of Infection and Chemotherapy",

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publisher = "Elsevier BV",

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Yasuda, M, Takahashi, S, Miyazaki, J, Wada, K, Kobayashi, K, Matsumoto, M, Hayami, H, Yamamoto, S, Kiyota, H, Sato, J, Matsumoto, T, Yotsuyanagi, H, Hanaki, H, Masumori, N, Hiyama, Y, Nishiyama, H, Kimura, T, Yamada, H, Matsumoto, K, Ishikawa, K, Togo, Y, Tanaka, K, Sadahira, T, Inokuchi, J, Hamasuna, R, Ito, K, Hirayama, H, Hayashi, K, Kurimura, Y, Kadena, H, Ito, S, Shiono, Y, Maruyama, T, Ito, M, Hatano, K, Chokyu, H, Ihara, H, Uno, S, Monden, K, Yokoyama, T, Kano, M, Kaji, S, Kawahara, M, Sumii, T, Tojo, T, Hosobe, T, Naito, K, Kawai, S, Nishimura, H, Izumitani, M, Yoh, M, Matsumura, M, Fujita, R, Takayama, K, Hara, M & Nishi, S 2023, 'The third nationwide surveillance of antimicrobial susceptibility against Neisseria gonorrhoeae from male urethritis in Japan, 2016–2017', Journal of Infection and Chemotherapy, vol. 29, no. 11, pp. 1011-1016. https://doi.org/10.1016/j.jiac.2023.08.003

TY - JOUR

T1 - The third nationwide surveillance of antimicrobial susceptibility against Neisseria gonorrhoeae from male urethritis in Japan, 2016–2017

AU - Yasuda, Mitsuru

AU - Takahashi, Satoshi

AU - Miyazaki, Jun

AU - Wada, Koichiro

AU - Kobayashi, Kanao

AU - Matsumoto, Masahiro

AU - Hayami, Hiroshi

AU - Yamamoto, Shingo

AU - Kiyota, Hiroshi

AU - Sato, Junko

AU - Matsumoto, Tetsuya

AU - Yotsuyanagi, Hiroshi

AU - Hanaki, Hideaki

AU - Masumori, Naoya

AU - Hiyama, Yoshiki

AU - Nishiyama, Hiroyuki

AU - Kimura, Takahiro

AU - Yamada, Hiroki

AU - Matsumoto, Kazumasa

AU - Ishikawa, Kiyohito

AU - Togo, Yoshikazu

AU - Tanaka, Kazushi

AU - Sadahira, Takuya

AU - Inokuchi, Junichi

AU - Hamasuna, Ryoichi

AU - Ito, Kenji

AU - Hirayama, Hideo

AU - Hayashi, Kenji

AU - Kurimura, Yuichiro

AU - Kadena, Hitoshi

AU - Ito, Shin

AU - Shiono, Yutaka

AU - Maruyama, Takahiro

AU - Ito, Masayasu

AU - Hatano, Koichi

AU - Chokyu, Hirofumi

AU - Ihara, Hideari

AU - Uno, Satoshi

AU - Monden, Koichi

AU - Yokoyama, Teruhiko

AU - Kano, Motonori

AU - Kaji, Shinichi

AU - Kawahara, Motoshi

AU - Sumii, Toru

AU - Tojo, Takanori

AU - Hosobe, Takahide

AU - Naito, Kazuhiko

AU - Kawai, Shuichi

AU - Nishimura, Hirofumi

AU - Izumitani, Masanobu

AU - Yoh, Mutsumasa

AU - Matsumura, Masaru

AU - Fujita, Ryuji

AU - Takayama, Kazuo

AU - Hara, Makoto

AU - Nishi, Shohei

PY - 2023/11

Y1 - 2023/11

N2 - Neisseria gonorrhoeae is one of the important pathogens of sexually transmitted infections. N. gonorrhoeae is rapidly becoming antimicrobial resistant, and there are few drugs that are effective in the initial treatment of gonorrhea. To understand the trends of antimicrobial susceptibility of N. gonorrhoeae, the Surveillance Committee of the Japanese Society of Infectious Diseases, the Japanese Society for Chemotherapy, and the Japanese Society of Clinical Microbiology conducted the third nationwide antimicrobial susceptibility surveillance of N. gonorrhoeae isolated from male urethritis. The specimens were collected from male patients with urethritis at 30 facilities from May 2016 to July 2017. From the 159 specimens collected, 87 N. gonorrhoeae strains were isolated, and 85 were tested for susceptibility to 21 antimicrobial agents. All strains were non-susceptible to penicillin G. Seven strains (8.2%) were β-lactamase-producing strains. The rates of susceptibility to cefixime and cefpodoxime were 96.5% and 52.9%, respectively. Three strains were non-susceptible with a minimum inhibitory concentration (MIC) of 0.5 mg/L for cefixime. None of the strains were resistant to ceftriaxone or spectinomycin. The susceptibility rate for ciprofloxacin was 23.5% (20 strains), and no strains showed intermediate susceptibility. The susceptibility rate against azithromycin was 81.2%, with one strain isolated with a MIC of 8 mg/L against azithromycin. The results of this surveillance indicate that ceftriaxone and spectinomycin, which are currently recommended for gonococcal infections in Japan, appear to be effective. It will be necessary to further expand the scale of the next surveillance to understand the current status of drug-resistant N. gonorrhoeae in Japan.

AB - Neisseria gonorrhoeae is one of the important pathogens of sexually transmitted infections. N. gonorrhoeae is rapidly becoming antimicrobial resistant, and there are few drugs that are effective in the initial treatment of gonorrhea. To understand the trends of antimicrobial susceptibility of N. gonorrhoeae, the Surveillance Committee of the Japanese Society of Infectious Diseases, the Japanese Society for Chemotherapy, and the Japanese Society of Clinical Microbiology conducted the third nationwide antimicrobial susceptibility surveillance of N. gonorrhoeae isolated from male urethritis. The specimens were collected from male patients with urethritis at 30 facilities from May 2016 to July 2017. From the 159 specimens collected, 87 N. gonorrhoeae strains were isolated, and 85 were tested for susceptibility to 21 antimicrobial agents. All strains were non-susceptible to penicillin G. Seven strains (8.2%) were β-lactamase-producing strains. The rates of susceptibility to cefixime and cefpodoxime were 96.5% and 52.9%, respectively. Three strains were non-susceptible with a minimum inhibitory concentration (MIC) of 0.5 mg/L for cefixime. None of the strains were resistant to ceftriaxone or spectinomycin. The susceptibility rate for ciprofloxacin was 23.5% (20 strains), and no strains showed intermediate susceptibility. The susceptibility rate against azithromycin was 81.2%, with one strain isolated with a MIC of 8 mg/L against azithromycin. The results of this surveillance indicate that ceftriaxone and spectinomycin, which are currently recommended for gonococcal infections in Japan, appear to be effective. It will be necessary to further expand the scale of the next surveillance to understand the current status of drug-resistant N. gonorrhoeae in Japan.

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SN - 1341-321X

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JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

IS - 11

ER -

The third nationwide surveillance of antimicrobial susceptibility against Neisseria gonorrhoeae from male urethritis in Japan, 2016–2017

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