The Trajectory of the COVID-19 Vaccine Antibody Titers Over Time and the Association of Mycophenolate Mofetil in Solid Organ Transplant Recipients

Akiyoshi Sakai, Tetsuji Morishita, Kaori Suzumura, Fumika Hanatate, Tomomi Yoshikawa, Noriko Sasaki, Shin Lee, Kei Fujita, Takeshi Hara, Hiroshi Araki, Atsushi Tagami, Masanori Murayama, Rie Yamada, Akira Iwata, Takuya Sobajima, Yukiko Kasahara, Yoriko Matsuzawa, Masao Takemura, Yasuko Yamamoto, Hidetsugu FujigakiKuniaki Saito, Hisashi Tsurumi, Hidetoshi Matsunami

Research output: Contribution to journalArticlepeer-review

Abstract

The COVID-19 vaccine will be safe and effective in solid organ transplant recipients (SOTs). However, the blunted antibody responses were also of concern. Few studies have reported prolonged serologic follow-up after 2 doses of BNT162b2 vaccine in SOTs. We performed a single-center, prospective observational study of 78 SOTs who received 2 doses of BNT162b2 vaccine. We identified the trajectory of antibody titers after vaccination among SOTs with or without mycophenolate mofetil (MMF) or withdrawn from MMF. We found low seroconversion rates (29/42: 69%) and low antibody titers in SOTs treated with MMF. An inverse linear relationship between neutralizing antibody titers and MMF concentration was confirmed in restricted cubic spline plots (P for effect < .01, P for nonlinearity = .08). For the trajectory of antibody responses, seroconversion and improved antibody titers were observed after withdrawal from MMF in SOTs who showed seronegative or low antibody titers at the first visit after 2 doses of vaccine (P for effect < .01, P for nonlinearity < .05, and P for interaction < .01). We identified increased B-cell counts after withdrawal from MMF (P < .01). The recovery of antibody responses was seen in SOTs withdrawn from MMF. The trajectories of antibody responses were modified by MMF administration.

Original languageEnglish
Pages (from-to)2638-2645
Number of pages8
JournalTransplantation Proceedings
Volume54
Issue number10
DOIs
Publication statusPublished - 12-2022

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Fingerprint

Dive into the research topics of 'The Trajectory of the COVID-19 Vaccine Antibody Titers Over Time and the Association of Mycophenolate Mofetil in Solid Organ Transplant Recipients'. Together they form a unique fingerprint.

Cite this