TY - JOUR
T1 - The Trajectory of the COVID-19 Vaccine Antibody Titers Over Time and the Association of Mycophenolate Mofetil in Solid Organ Transplant Recipients
AU - Sakai, Akiyoshi
AU - Morishita, Tetsuji
AU - Suzumura, Kaori
AU - Hanatate, Fumika
AU - Yoshikawa, Tomomi
AU - Sasaki, Noriko
AU - Lee, Shin
AU - Fujita, Kei
AU - Hara, Takeshi
AU - Araki, Hiroshi
AU - Tagami, Atsushi
AU - Murayama, Masanori
AU - Yamada, Rie
AU - Iwata, Akira
AU - Sobajima, Takuya
AU - Kasahara, Yukiko
AU - Matsuzawa, Yoriko
AU - Takemura, Masao
AU - Yamamoto, Yasuko
AU - Fujigaki, Hidetsugu
AU - Saito, Kuniaki
AU - Tsurumi, Hisashi
AU - Matsunami, Hidetoshi
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/12
Y1 - 2022/12
N2 - The COVID-19 vaccine will be safe and effective in solid organ transplant recipients (SOTs). However, the blunted antibody responses were also of concern. Few studies have reported prolonged serologic follow-up after 2 doses of BNT162b2 vaccine in SOTs. We performed a single-center, prospective observational study of 78 SOTs who received 2 doses of BNT162b2 vaccine. We identified the trajectory of antibody titers after vaccination among SOTs with or without mycophenolate mofetil (MMF) or withdrawn from MMF. We found low seroconversion rates (29/42: 69%) and low antibody titers in SOTs treated with MMF. An inverse linear relationship between neutralizing antibody titers and MMF concentration was confirmed in restricted cubic spline plots (P for effect < .01, P for nonlinearity = .08). For the trajectory of antibody responses, seroconversion and improved antibody titers were observed after withdrawal from MMF in SOTs who showed seronegative or low antibody titers at the first visit after 2 doses of vaccine (P for effect < .01, P for nonlinearity < .05, and P for interaction < .01). We identified increased B-cell counts after withdrawal from MMF (P < .01). The recovery of antibody responses was seen in SOTs withdrawn from MMF. The trajectories of antibody responses were modified by MMF administration.
AB - The COVID-19 vaccine will be safe and effective in solid organ transplant recipients (SOTs). However, the blunted antibody responses were also of concern. Few studies have reported prolonged serologic follow-up after 2 doses of BNT162b2 vaccine in SOTs. We performed a single-center, prospective observational study of 78 SOTs who received 2 doses of BNT162b2 vaccine. We identified the trajectory of antibody titers after vaccination among SOTs with or without mycophenolate mofetil (MMF) or withdrawn from MMF. We found low seroconversion rates (29/42: 69%) and low antibody titers in SOTs treated with MMF. An inverse linear relationship between neutralizing antibody titers and MMF concentration was confirmed in restricted cubic spline plots (P for effect < .01, P for nonlinearity = .08). For the trajectory of antibody responses, seroconversion and improved antibody titers were observed after withdrawal from MMF in SOTs who showed seronegative or low antibody titers at the first visit after 2 doses of vaccine (P for effect < .01, P for nonlinearity < .05, and P for interaction < .01). We identified increased B-cell counts after withdrawal from MMF (P < .01). The recovery of antibody responses was seen in SOTs withdrawn from MMF. The trajectories of antibody responses were modified by MMF administration.
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U2 - 10.1016/j.transproceed.2022.10.023
DO - 10.1016/j.transproceed.2022.10.023
M3 - Article
C2 - 36372567
AN - SCOPUS:85141812810
SN - 0041-1345
VL - 54
SP - 2638
EP - 2645
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 10
ER -