The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state

Koji Tamakoshi, Hiroshi Yatsuya, Keiko Wada, Kunihiro Matsushita, Rei Otsuka, Pei Ou Yang, Kaichiro Sugiura, Yo Hotta, Hirotsugu Mitsuhashi, Seiko Takefuji, Takaaki Kondo, Hideaki Toyoshima

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Abstract

Objective: To evaluate the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status. Subjects: We conducted a population-based, cross-sectional study of 207 premenopausal and 206 postmenopausal Japanese women. Measurements: Data on anthropometric characteristics, fasting serum adiponectin, glucose and insulin concentrations were used. Insulin resistance (homeostasis model assessment of insulin resistance: HOMA-IR) was calculated. Results: Postmenopausal women had significantly higher HOMA-IRs than premenopausal women [1.50 (1.42, 1.59) vs 1.18 (1.12, 1.24), geometric mean (1 standard error range), P = 0.005]. Paradoxically, adiponectin levels in postmenopausal women were also significantly higher than those in premenopausal women [10.3 (9.95, 10.7) vs 9.04 (8.71, 9.39), P = 0.028]. Multiple regression analysis showed that body mass index (BMI) was the only significantly independent predictor [standardized partial regression coefficients (sβ) = 0.319, P < 0.001] for HOMA-IR among premenopausal women, whereas both BMI and adiponectin were the significant predictors among postmenopausal (sβ = 0.334 and -0.141, P < 0.001 and < 0.05, respectively). When the subjects were restricted to those without metabolic disorders including high blood pressure, hypertriglyceridaemia, hypo-HDL cholesterolaemia and high fasting glucose, adiponectin (sβ = -0.249, P < 0.05) was the only significant predictor for HOMA-IR among postmenopausal women but BMI was not significant (sβ = 0.223, P = 0.075). Conclusions: The transition to menopause increases serum adiponectin concentrations. And the significant and negative association between adiponectin and HOMA-IR was observed only after menopause. Therefore, adiponectin may play a role in the improvement of an incipient insulin-resistant state after, rather than before, menopause.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalClinical Endocrinology
Volume66
Issue number1
DOIs
Publication statusPublished - 01-01-2007
Externally publishedYes

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Adiponectin
Menopause
Insulin
Insulin Resistance
Body Mass Index
Fasting
Serum
Glucose
Hypertriglyceridemia
Homeostasis
Cross-Sectional Studies
Regression Analysis
Hypertension

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Tamakoshi, Koji ; Yatsuya, Hiroshi ; Wada, Keiko ; Matsushita, Kunihiro ; Otsuka, Rei ; Yang, Pei Ou ; Sugiura, Kaichiro ; Hotta, Yo ; Mitsuhashi, Hirotsugu ; Takefuji, Seiko ; Kondo, Takaaki ; Toyoshima, Hideaki. / The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state. In: Clinical Endocrinology. 2007 ; Vol. 66, No. 1. pp. 65-71.
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abstract = "Objective: To evaluate the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status. Subjects: We conducted a population-based, cross-sectional study of 207 premenopausal and 206 postmenopausal Japanese women. Measurements: Data on anthropometric characteristics, fasting serum adiponectin, glucose and insulin concentrations were used. Insulin resistance (homeostasis model assessment of insulin resistance: HOMA-IR) was calculated. Results: Postmenopausal women had significantly higher HOMA-IRs than premenopausal women [1.50 (1.42, 1.59) vs 1.18 (1.12, 1.24), geometric mean (1 standard error range), P = 0.005]. Paradoxically, adiponectin levels in postmenopausal women were also significantly higher than those in premenopausal women [10.3 (9.95, 10.7) vs 9.04 (8.71, 9.39), P = 0.028]. Multiple regression analysis showed that body mass index (BMI) was the only significantly independent predictor [standardized partial regression coefficients (sβ) = 0.319, P < 0.001] for HOMA-IR among premenopausal women, whereas both BMI and adiponectin were the significant predictors among postmenopausal (sβ = 0.334 and -0.141, P < 0.001 and < 0.05, respectively). When the subjects were restricted to those without metabolic disorders including high blood pressure, hypertriglyceridaemia, hypo-HDL cholesterolaemia and high fasting glucose, adiponectin (sβ = -0.249, P < 0.05) was the only significant predictor for HOMA-IR among postmenopausal women but BMI was not significant (sβ = 0.223, P = 0.075). Conclusions: The transition to menopause increases serum adiponectin concentrations. And the significant and negative association between adiponectin and HOMA-IR was observed only after menopause. Therefore, adiponectin may play a role in the improvement of an incipient insulin-resistant state after, rather than before, menopause.",
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Tamakoshi, K, Yatsuya, H, Wada, K, Matsushita, K, Otsuka, R, Yang, PO, Sugiura, K, Hotta, Y, Mitsuhashi, H, Takefuji, S, Kondo, T & Toyoshima, H 2007, 'The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state', Clinical Endocrinology, vol. 66, no. 1, pp. 65-71. https://doi.org/10.1111/j.1365-2265.2006.02687.x

The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state. / Tamakoshi, Koji; Yatsuya, Hiroshi; Wada, Keiko; Matsushita, Kunihiro; Otsuka, Rei; Yang, Pei Ou; Sugiura, Kaichiro; Hotta, Yo; Mitsuhashi, Hirotsugu; Takefuji, Seiko; Kondo, Takaaki; Toyoshima, Hideaki.

In: Clinical Endocrinology, Vol. 66, No. 1, 01.01.2007, p. 65-71.

Research output: Contribution to journalArticle

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T1 - The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state

AU - Tamakoshi, Koji

AU - Yatsuya, Hiroshi

AU - Wada, Keiko

AU - Matsushita, Kunihiro

AU - Otsuka, Rei

AU - Yang, Pei Ou

AU - Sugiura, Kaichiro

AU - Hotta, Yo

AU - Mitsuhashi, Hirotsugu

AU - Takefuji, Seiko

AU - Kondo, Takaaki

AU - Toyoshima, Hideaki

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Objective: To evaluate the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status. Subjects: We conducted a population-based, cross-sectional study of 207 premenopausal and 206 postmenopausal Japanese women. Measurements: Data on anthropometric characteristics, fasting serum adiponectin, glucose and insulin concentrations were used. Insulin resistance (homeostasis model assessment of insulin resistance: HOMA-IR) was calculated. Results: Postmenopausal women had significantly higher HOMA-IRs than premenopausal women [1.50 (1.42, 1.59) vs 1.18 (1.12, 1.24), geometric mean (1 standard error range), P = 0.005]. Paradoxically, adiponectin levels in postmenopausal women were also significantly higher than those in premenopausal women [10.3 (9.95, 10.7) vs 9.04 (8.71, 9.39), P = 0.028]. Multiple regression analysis showed that body mass index (BMI) was the only significantly independent predictor [standardized partial regression coefficients (sβ) = 0.319, P < 0.001] for HOMA-IR among premenopausal women, whereas both BMI and adiponectin were the significant predictors among postmenopausal (sβ = 0.334 and -0.141, P < 0.001 and < 0.05, respectively). When the subjects were restricted to those without metabolic disorders including high blood pressure, hypertriglyceridaemia, hypo-HDL cholesterolaemia and high fasting glucose, adiponectin (sβ = -0.249, P < 0.05) was the only significant predictor for HOMA-IR among postmenopausal women but BMI was not significant (sβ = 0.223, P = 0.075). Conclusions: The transition to menopause increases serum adiponectin concentrations. And the significant and negative association between adiponectin and HOMA-IR was observed only after menopause. Therefore, adiponectin may play a role in the improvement of an incipient insulin-resistant state after, rather than before, menopause.

AB - Objective: To evaluate the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status. Subjects: We conducted a population-based, cross-sectional study of 207 premenopausal and 206 postmenopausal Japanese women. Measurements: Data on anthropometric characteristics, fasting serum adiponectin, glucose and insulin concentrations were used. Insulin resistance (homeostasis model assessment of insulin resistance: HOMA-IR) was calculated. Results: Postmenopausal women had significantly higher HOMA-IRs than premenopausal women [1.50 (1.42, 1.59) vs 1.18 (1.12, 1.24), geometric mean (1 standard error range), P = 0.005]. Paradoxically, adiponectin levels in postmenopausal women were also significantly higher than those in premenopausal women [10.3 (9.95, 10.7) vs 9.04 (8.71, 9.39), P = 0.028]. Multiple regression analysis showed that body mass index (BMI) was the only significantly independent predictor [standardized partial regression coefficients (sβ) = 0.319, P < 0.001] for HOMA-IR among premenopausal women, whereas both BMI and adiponectin were the significant predictors among postmenopausal (sβ = 0.334 and -0.141, P < 0.001 and < 0.05, respectively). When the subjects were restricted to those without metabolic disorders including high blood pressure, hypertriglyceridaemia, hypo-HDL cholesterolaemia and high fasting glucose, adiponectin (sβ = -0.249, P < 0.05) was the only significant predictor for HOMA-IR among postmenopausal women but BMI was not significant (sβ = 0.223, P = 0.075). Conclusions: The transition to menopause increases serum adiponectin concentrations. And the significant and negative association between adiponectin and HOMA-IR was observed only after menopause. Therefore, adiponectin may play a role in the improvement of an incipient insulin-resistant state after, rather than before, menopause.

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