The washout rate of 123I-BMIPP and the evolution of left ventricular function in patients with successfully reperfused ST-segment elevation myocardial infarction: Comparisons with the echocardiography

Shankar K. Biswas, Masayoshi Sarai, Akira Yamada, Hiroshi Toyama, Sadako Motoyama, Hiroto Harigaya, Tomonori Hara, Hiroyuki Naruse, Hitoshi Hishida, Yukio Ozaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The evolution of the oxidative metabolism of 11C acetate parallels the recovery of left ventricular (LV) contraction following acute myocardial infarction (AMI). This study was designed to unravel, for the first time, the impact of the global washout rate (WR) of 123I-β- methyl-p-iodophenylpentadecanoic acid (BMIPP) on the recovery of LV function following AMI, as evidenced from conventional echocardiography. Twenty consecutive patients (age: 58 ± 13 years; 16 males and 4 females) with ST-segment elevation myocardial infarction (STEMI) were enrolled and all of them underwent successful percutaneous coronary intervention (PCI). 123I-BMIPP cardiac scintigraphy was performed at 7 ± 3 days after admission. The WR was calculated from the polar map and the regional BMIPP defect score was calculated using a 17 segment model. Echocardiography was performed within 24 h of admission and at 3 months to record the ejection fraction (EF), the wall motion score index (WMSI), the ratio of the mitral inflow velocity to the early diastolic velocity (E/E?) and the myocardial performance index (MPI). The mean global WR of the BMIPP was 22.12 ± 7.22%, and it was significantly correlated with the improvement of the WMSI (r = 0.61, P < 0.004). However, the relative changes of the EF, E/E? and MPI were not correlated with the WR. The BMIPP defect score (18 ± 10) was significantly correlated with the WMSI on admission (r = 0.74, P = 0.0002), but the defect score was not correlated with the relative changes of any of the echocardiographic parameters. We proved that the WR of the BMIPP is a promising indicator of improvement of the LV wall motion (WMSI) following ST-segment elevation myocardial infarction and successful reperfusion.

Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalInternational Journal of Cardiovascular Imaging
Volume26
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 01-02-2010

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this