The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence

Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Naohiko Uchida, Akira Nomura, Kyohei Otani, Makiko Kishimoto, Akiko Morio, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Bipolar disorder has known as a high risk factor for substance abuse and dependence such as alcohol and illegal drugs. Recently, Kakiuchi et al. reported that the -116C/G polymorphism in the promoter region of the X-box binding protein 1 (XBP-1) gene, which translates a transcription factor specific for endoplasmic reticulum stress caused by misfolded proteins, was associated with bipolar disorders and schizophrenia in a Japanese population. Abuse of methamphetamine often produces affective disorders such as manic state, depressive state, and psychosis resembling paranoid-type schizophrenia. To clarify a possible involvement of XBP-1 in the etiology of methamphetamine dependence, we examined the genetic association of the -116C/G polymorphism of the XBP-1 gene by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism either with methamphetamine dependence or any clinical phenotype of dependence. Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence.

Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalNeuroscience Letters
Volume383
Issue number1-2
DOIs
Publication statusPublished - 22-07-2005

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Methamphetamine
Bipolar Disorder
Genes
Genetic Promoter Regions
Substance-Related Disorders
Paranoid Schizophrenia
Endoplasmic Reticulum Stress
Mood Disorders
Gene Frequency
Psychotic Disorders
Case-Control Studies
Schizophrenia
Transcription Factors
Genotype
Alcohols
X-Box Binding Protein 1
Phenotype
Pharmaceutical Preparations
Population
Proteins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Morita, Y., Ujike, H., Tanaka, Y., Uchida, N., Nomura, A., Otani, K., ... Ozaki, N. (2005). The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. Neuroscience Letters, 383(1-2), 194-198. https://doi.org/10.1016/j.neulet.2005.04.014
Morita, Yukitaka ; Ujike, Hiroshi ; Tanaka, Yuji ; Uchida, Naohiko ; Nomura, Akira ; Otani, Kyohei ; Kishimoto, Makiko ; Morio, Akiko ; Inada, Toshiya ; Harano, Mutsuo ; Komiyama, Tokutaro ; Yamada, Mitsuhiko ; Sekine, Yoshimoto ; Iwata, Nakao ; Iyo, Masaomi ; Sora, Ichiro ; Ozaki, Norio. / The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. In: Neuroscience Letters. 2005 ; Vol. 383, No. 1-2. pp. 194-198.
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abstract = "Bipolar disorder has known as a high risk factor for substance abuse and dependence such as alcohol and illegal drugs. Recently, Kakiuchi et al. reported that the -116C/G polymorphism in the promoter region of the X-box binding protein 1 (XBP-1) gene, which translates a transcription factor specific for endoplasmic reticulum stress caused by misfolded proteins, was associated with bipolar disorders and schizophrenia in a Japanese population. Abuse of methamphetamine often produces affective disorders such as manic state, depressive state, and psychosis resembling paranoid-type schizophrenia. To clarify a possible involvement of XBP-1 in the etiology of methamphetamine dependence, we examined the genetic association of the -116C/G polymorphism of the XBP-1 gene by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism either with methamphetamine dependence or any clinical phenotype of dependence. Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence.",
author = "Yukitaka Morita and Hiroshi Ujike and Yuji Tanaka and Naohiko Uchida and Akira Nomura and Kyohei Otani and Makiko Kishimoto and Akiko Morio and Toshiya Inada and Mutsuo Harano and Tokutaro Komiyama and Mitsuhiko Yamada and Yoshimoto Sekine and Nakao Iwata and Masaomi Iyo and Ichiro Sora and Norio Ozaki",
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Morita, Y, Ujike, H, Tanaka, Y, Uchida, N, Nomura, A, Otani, K, Kishimoto, M, Morio, A, Inada, T, Harano, M, Komiyama, T, Yamada, M, Sekine, Y, Iwata, N, Iyo, M, Sora, I & Ozaki, N 2005, 'The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence', Neuroscience Letters, vol. 383, no. 1-2, pp. 194-198. https://doi.org/10.1016/j.neulet.2005.04.014

The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. / Morita, Yukitaka; Ujike, Hiroshi; Tanaka, Yuji; Uchida, Naohiko; Nomura, Akira; Otani, Kyohei; Kishimoto, Makiko; Morio, Akiko; Inada, Toshiya; Harano, Mutsuo; Komiyama, Tokutaro; Yamada, Mitsuhiko; Sekine, Yoshimoto; Iwata, Nakao; Iyo, Masaomi; Sora, Ichiro; Ozaki, Norio.

In: Neuroscience Letters, Vol. 383, No. 1-2, 22.07.2005, p. 194-198.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence

AU - Morita, Yukitaka

AU - Ujike, Hiroshi

AU - Tanaka, Yuji

AU - Uchida, Naohiko

AU - Nomura, Akira

AU - Otani, Kyohei

AU - Kishimoto, Makiko

AU - Morio, Akiko

AU - Inada, Toshiya

AU - Harano, Mutsuo

AU - Komiyama, Tokutaro

AU - Yamada, Mitsuhiko

AU - Sekine, Yoshimoto

AU - Iwata, Nakao

AU - Iyo, Masaomi

AU - Sora, Ichiro

AU - Ozaki, Norio

PY - 2005/7/22

Y1 - 2005/7/22

N2 - Bipolar disorder has known as a high risk factor for substance abuse and dependence such as alcohol and illegal drugs. Recently, Kakiuchi et al. reported that the -116C/G polymorphism in the promoter region of the X-box binding protein 1 (XBP-1) gene, which translates a transcription factor specific for endoplasmic reticulum stress caused by misfolded proteins, was associated with bipolar disorders and schizophrenia in a Japanese population. Abuse of methamphetamine often produces affective disorders such as manic state, depressive state, and psychosis resembling paranoid-type schizophrenia. To clarify a possible involvement of XBP-1 in the etiology of methamphetamine dependence, we examined the genetic association of the -116C/G polymorphism of the XBP-1 gene by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism either with methamphetamine dependence or any clinical phenotype of dependence. Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence.

AB - Bipolar disorder has known as a high risk factor for substance abuse and dependence such as alcohol and illegal drugs. Recently, Kakiuchi et al. reported that the -116C/G polymorphism in the promoter region of the X-box binding protein 1 (XBP-1) gene, which translates a transcription factor specific for endoplasmic reticulum stress caused by misfolded proteins, was associated with bipolar disorders and schizophrenia in a Japanese population. Abuse of methamphetamine often produces affective disorders such as manic state, depressive state, and psychosis resembling paranoid-type schizophrenia. To clarify a possible involvement of XBP-1 in the etiology of methamphetamine dependence, we examined the genetic association of the -116C/G polymorphism of the XBP-1 gene by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism either with methamphetamine dependence or any clinical phenotype of dependence. Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence.

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