TY - JOUR
T1 - The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence
AU - Morita, Yukitaka
AU - Ujike, Hiroshi
AU - Tanaka, Yuji
AU - Uchida, Naohiko
AU - Nomura, Akira
AU - Otani, Kyohei
AU - Kishimoto, Makiko
AU - Morio, Akiko
AU - Inada, Toshiya
AU - Harano, Mutsuo
AU - Komiyama, Tokutaro
AU - Yamada, Mitsuhiko
AU - Sekine, Yoshimoto
AU - Iwata, Nakao
AU - Iyo, Masaomi
AU - Sora, Ichiro
AU - Ozaki, Norio
N1 - Funding Information:
The authors are grateful to the Zikei Institute of Psychiatry (Okayama, Japan), the Ministry of Health, Labour and Welfare of Japan, and the Ministry of Education, Culture, Sports, Science and Technology of Japan for support in part by grants.
PY - 2005/7/22
Y1 - 2005/7/22
N2 - Bipolar disorder has known as a high risk factor for substance abuse and dependence such as alcohol and illegal drugs. Recently, Kakiuchi et al. reported that the -116C/G polymorphism in the promoter region of the X-box binding protein 1 (XBP-1) gene, which translates a transcription factor specific for endoplasmic reticulum stress caused by misfolded proteins, was associated with bipolar disorders and schizophrenia in a Japanese population. Abuse of methamphetamine often produces affective disorders such as manic state, depressive state, and psychosis resembling paranoid-type schizophrenia. To clarify a possible involvement of XBP-1 in the etiology of methamphetamine dependence, we examined the genetic association of the -116C/G polymorphism of the XBP-1 gene by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism either with methamphetamine dependence or any clinical phenotype of dependence. Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence.
AB - Bipolar disorder has known as a high risk factor for substance abuse and dependence such as alcohol and illegal drugs. Recently, Kakiuchi et al. reported that the -116C/G polymorphism in the promoter region of the X-box binding protein 1 (XBP-1) gene, which translates a transcription factor specific for endoplasmic reticulum stress caused by misfolded proteins, was associated with bipolar disorders and schizophrenia in a Japanese population. Abuse of methamphetamine often produces affective disorders such as manic state, depressive state, and psychosis resembling paranoid-type schizophrenia. To clarify a possible involvement of XBP-1 in the etiology of methamphetamine dependence, we examined the genetic association of the -116C/G polymorphism of the XBP-1 gene by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism either with methamphetamine dependence or any clinical phenotype of dependence. Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence.
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U2 - 10.1016/j.neulet.2005.04.014
DO - 10.1016/j.neulet.2005.04.014
M3 - Article
C2 - 15936534
AN - SCOPUS:20344367034
SN - 0304-3940
VL - 383
SP - 194
EP - 198
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -