Theanine attenuates memory impairments induced by: Klotho gene depletion in mice

Bao Trong Nguyen, Naveen Sharma, Eun Joo Shin, Ji Hoon Jeong, Sung Hoon Lee, Choon Gon Jang, Seung Yeol Nah, Toshitaka Nabeshima, Yukio Yoneda, Hyoung Chun Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Theanine (γ-glutamylethylamide), an amino acid in tea, is a putative neuroprotective and antioxidant compound capable of improving lifespan and cognitive function. Because we previously reported cognitive dysfunction in klotho mutant mice via down-regulation of janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3), M1 muscarinic cholinergic receptor (M1 mAChR), and ERK signaling, we, therefore, investigated whether self-administration of theanine affects memory dysfunction in response to klotho gene depletion in mice, and whether theanine modulates the JAK2/STAT3, M1 mAChR, and ERK signaling network. Theanine significantly attenuated memory impairments in klotho mutant mice. Moreover, theanine self-administration significantly attenuated inhibitions of JAK2/STAT3 phosphorylation, M1 mAChR expression, and ERK 1/2 phosphorylation in the hippocampus of klotho mutant mice. Consistently, AG490, a JAK2/STAT3 inhibitor, dicyclomine, an M1 mAChR antagonist, or U0126, an ERK 1/2 inhibitor, significantly counteracted theanine-induced attenuation of memory impairment induced by klotho gene depletion in mice. Our study suggests that theanine attenuates memory impairments in a genetic aging model via up-regulation of JAK2/STAT3, M1 mAChR, and ERK signaling.

Original languageEnglish
Pages (from-to)325-332
Number of pages8
JournalFood and Function
Volume10
Issue number1
DOIs
Publication statusPublished - 01-01-2019

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theanine
non-specific protein-tyrosine kinase
Janus Kinase 2
cholinergic receptors
Muscarinic Receptors
Transducers
Cholinergic Receptors
mice
Genes
genes
Self Administration
mutants
Dicyclomine
phosphorylation
Phosphorylation
Genetic Models
Cholinergic Antagonists
Tea
hippocampus
cognition

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Nguyen, B. T., Sharma, N., Shin, E. J., Jeong, J. H., Lee, S. H., Jang, C. G., ... Kim, H. C. (2019). Theanine attenuates memory impairments induced by: Klotho gene depletion in mice. Food and Function, 10(1), 325-332. https://doi.org/10.1039/c8fo01577e
Nguyen, Bao Trong ; Sharma, Naveen ; Shin, Eun Joo ; Jeong, Ji Hoon ; Lee, Sung Hoon ; Jang, Choon Gon ; Nah, Seung Yeol ; Nabeshima, Toshitaka ; Yoneda, Yukio ; Kim, Hyoung Chun. / Theanine attenuates memory impairments induced by : Klotho gene depletion in mice. In: Food and Function. 2019 ; Vol. 10, No. 1. pp. 325-332.
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abstract = "Theanine (γ-glutamylethylamide), an amino acid in tea, is a putative neuroprotective and antioxidant compound capable of improving lifespan and cognitive function. Because we previously reported cognitive dysfunction in klotho mutant mice via down-regulation of janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3), M1 muscarinic cholinergic receptor (M1 mAChR), and ERK signaling, we, therefore, investigated whether self-administration of theanine affects memory dysfunction in response to klotho gene depletion in mice, and whether theanine modulates the JAK2/STAT3, M1 mAChR, and ERK signaling network. Theanine significantly attenuated memory impairments in klotho mutant mice. Moreover, theanine self-administration significantly attenuated inhibitions of JAK2/STAT3 phosphorylation, M1 mAChR expression, and ERK 1/2 phosphorylation in the hippocampus of klotho mutant mice. Consistently, AG490, a JAK2/STAT3 inhibitor, dicyclomine, an M1 mAChR antagonist, or U0126, an ERK 1/2 inhibitor, significantly counteracted theanine-induced attenuation of memory impairment induced by klotho gene depletion in mice. Our study suggests that theanine attenuates memory impairments in a genetic aging model via up-regulation of JAK2/STAT3, M1 mAChR, and ERK signaling.",
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Nguyen, BT, Sharma, N, Shin, EJ, Jeong, JH, Lee, SH, Jang, CG, Nah, SY, Nabeshima, T, Yoneda, Y & Kim, HC 2019, 'Theanine attenuates memory impairments induced by: Klotho gene depletion in mice', Food and Function, vol. 10, no. 1, pp. 325-332. https://doi.org/10.1039/c8fo01577e

Theanine attenuates memory impairments induced by : Klotho gene depletion in mice. / Nguyen, Bao Trong; Sharma, Naveen; Shin, Eun Joo; Jeong, Ji Hoon; Lee, Sung Hoon; Jang, Choon Gon; Nah, Seung Yeol; Nabeshima, Toshitaka; Yoneda, Yukio; Kim, Hyoung Chun.

In: Food and Function, Vol. 10, No. 1, 01.01.2019, p. 325-332.

Research output: Contribution to journalArticle

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T1 - Theanine attenuates memory impairments induced by

T2 - Klotho gene depletion in mice

AU - Nguyen, Bao Trong

AU - Sharma, Naveen

AU - Shin, Eun Joo

AU - Jeong, Ji Hoon

AU - Lee, Sung Hoon

AU - Jang, Choon Gon

AU - Nah, Seung Yeol

AU - Nabeshima, Toshitaka

AU - Yoneda, Yukio

AU - Kim, Hyoung Chun

PY - 2019/1/1

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N2 - Theanine (γ-glutamylethylamide), an amino acid in tea, is a putative neuroprotective and antioxidant compound capable of improving lifespan and cognitive function. Because we previously reported cognitive dysfunction in klotho mutant mice via down-regulation of janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3), M1 muscarinic cholinergic receptor (M1 mAChR), and ERK signaling, we, therefore, investigated whether self-administration of theanine affects memory dysfunction in response to klotho gene depletion in mice, and whether theanine modulates the JAK2/STAT3, M1 mAChR, and ERK signaling network. Theanine significantly attenuated memory impairments in klotho mutant mice. Moreover, theanine self-administration significantly attenuated inhibitions of JAK2/STAT3 phosphorylation, M1 mAChR expression, and ERK 1/2 phosphorylation in the hippocampus of klotho mutant mice. Consistently, AG490, a JAK2/STAT3 inhibitor, dicyclomine, an M1 mAChR antagonist, or U0126, an ERK 1/2 inhibitor, significantly counteracted theanine-induced attenuation of memory impairment induced by klotho gene depletion in mice. Our study suggests that theanine attenuates memory impairments in a genetic aging model via up-regulation of JAK2/STAT3, M1 mAChR, and ERK signaling.

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Nguyen BT, Sharma N, Shin EJ, Jeong JH, Lee SH, Jang CG et al. Theanine attenuates memory impairments induced by: Klotho gene depletion in mice. Food and Function. 2019 Jan 1;10(1):325-332. https://doi.org/10.1039/c8fo01577e