Theanine attenuates memory impairments induced by: Klotho gene depletion in mice

Bao Trong Nguyen, Naveen Sharma, Eun Joo Shin, Ji Hoon Jeong, Sung Hoon Lee, Choon Gon Jang, Seung Yeol Nah, Toshitaka Nabeshima, Yukio Yoneda, Hyoung Chun Kim

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Theanine (γ-glutamylethylamide), an amino acid in tea, is a putative neuroprotective and antioxidant compound capable of improving lifespan and cognitive function. Because we previously reported cognitive dysfunction in klotho mutant mice via down-regulation of janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3), M1 muscarinic cholinergic receptor (M1 mAChR), and ERK signaling, we, therefore, investigated whether self-administration of theanine affects memory dysfunction in response to klotho gene depletion in mice, and whether theanine modulates the JAK2/STAT3, M1 mAChR, and ERK signaling network. Theanine significantly attenuated memory impairments in klotho mutant mice. Moreover, theanine self-administration significantly attenuated inhibitions of JAK2/STAT3 phosphorylation, M1 mAChR expression, and ERK 1/2 phosphorylation in the hippocampus of klotho mutant mice. Consistently, AG490, a JAK2/STAT3 inhibitor, dicyclomine, an M1 mAChR antagonist, or U0126, an ERK 1/2 inhibitor, significantly counteracted theanine-induced attenuation of memory impairment induced by klotho gene depletion in mice. Our study suggests that theanine attenuates memory impairments in a genetic aging model via up-regulation of JAK2/STAT3, M1 mAChR, and ERK signaling.

Original languageEnglish
Pages (from-to)325-332
Number of pages8
JournalFood and Function
Issue number1
Publication statusPublished - 01-2019

All Science Journal Classification (ASJC) codes

  • Food Science


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