Therapeutic Effect of Lisuride Maleate on Post-stroke Depression

Hidetaka Hougaku, Masayasu Matsumoto, Ryuji Hata, Nobuo Handa, Masatoshi Imaizumi, Yoshinori Sugitani, Shotaro Yoneda, Hideki Etani, Kenji Sueyoshi, Masahito Kusunoki, Takenobu Kamada, Osamu Uyama

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13 Citations (Scopus)


Twenty post-stroke depressive patients who obtained more than 11 points on Self-Rating Questionnaire for Depression, were treated with 0.075 mg/day lisuride maleate for 12 weeks. The drug effect on depression was evaluated quantitatively by the Hamilton Rating Scale for Depression. The relationships between brain CT or MRI and SRQ-D score were investigated in 24 subjects. More than 80% of post-stroke depressive patients improved after lisuride maleate treatment for 8 or 12 weeks. In particular, depressed mood, hypobulia, sleep disturbance, anxiety, etc. were significantly improved compared to the baseline condition. As for the relationships with CT and/or MRI findings, the group with moderate to severe brain atrophy had a significantly higher grade of depressive state than those without.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalNippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Issue number1
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology


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