Therapeutic Effect of Lisuride Maleate on Post-stroke Depression

Hidetaka Hougaku, Masayasu Matsumoto, Ryuji Hata, Nobuo Handa, Masatoshi Imaizumi, Yoshinori Sugitani, Shotaro Yoneda, Hideki Etani, Kenji Sueyoshi, Masahito Kusunoki, Takenobu Kamada, Osamu Uyama

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Twenty post-stroke depressive patients who obtained more than 11 points on Self-Rating Questionnaire for Depression, were treated with 0.075 mg/day lisuride maleate for 12 weeks. The drug effect on depression was evaluated quantitatively by the Hamilton Rating Scale for Depression. The relationships between brain CT or MRI and SRQ-D score were investigated in 24 subjects. More than 80% of post-stroke depressive patients improved after lisuride maleate treatment for 8 or 12 weeks. In particular, depressed mood, hypobulia, sleep disturbance, anxiety, etc. were significantly improved compared to the baseline condition. As for the relationships with CT and/or MRI findings, the group with moderate to severe brain atrophy had a significantly higher grade of depressive state than those without.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalNippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Volume31
Issue number1
DOIs
Publication statusPublished - 01-01-1994

Fingerprint

Lisuride
Therapeutic Uses
Stroke
Depression
Brain
Atrophy
Sleep
Anxiety
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Hougaku, Hidetaka ; Matsumoto, Masayasu ; Hata, Ryuji ; Handa, Nobuo ; Imaizumi, Masatoshi ; Sugitani, Yoshinori ; Yoneda, Shotaro ; Etani, Hideki ; Sueyoshi, Kenji ; Kusunoki, Masahito ; Kamada, Takenobu ; Uyama, Osamu. / Therapeutic Effect of Lisuride Maleate on Post-stroke Depression. In: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 1994 ; Vol. 31, No. 1. pp. 52-59.
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Hougaku, H, Matsumoto, M, Hata, R, Handa, N, Imaizumi, M, Sugitani, Y, Yoneda, S, Etani, H, Sueyoshi, K, Kusunoki, M, Kamada, T & Uyama, O 1994, 'Therapeutic Effect of Lisuride Maleate on Post-stroke Depression', Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, vol. 31, no. 1, pp. 52-59. https://doi.org/10.3143/geriatrics.31.52

Therapeutic Effect of Lisuride Maleate on Post-stroke Depression. / Hougaku, Hidetaka; Matsumoto, Masayasu; Hata, Ryuji; Handa, Nobuo; Imaizumi, Masatoshi; Sugitani, Yoshinori; Yoneda, Shotaro; Etani, Hideki; Sueyoshi, Kenji; Kusunoki, Masahito; Kamada, Takenobu; Uyama, Osamu.

In: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, Vol. 31, No. 1, 01.01.1994, p. 52-59.

Research output: Contribution to journalArticle

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