Therapeutic effect of Oren-gedoku-to extract on stress-induced acute gastric mucosal lesions in rats

Yoshiji Ohta, Takashi Kobayashi, Keiji Nishida, Minoru Nagata, Isao Ishiguro

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Oral administration of Oren-gedoku-to extract (TJ-15), a traditional Chinese herbal medicine for the therapy of gastric ulcers and gastritis, dose-dependently prevented the progression of acute gastric mucosal lesions in rats with water immersion restraint (WIR) stress. The preventive effect of TJ-15 on the lesion progression was stronger than that of Saiko-keishi-to extract (TJ-10) or Shigyaku-san extract (TJ-35), each of which is a traditional Chinese herbal medicine for the therapy of gastric ulcers and gastritis, when compared on the basis of a single dosage of each medicine for adults. This TJ-15 administration attenuated increases in gastric mucosal lipid peroxide concentration and xanthine oxidase and myeloperoxidase activities with the gastric mucosal lesion progression and recovered the decreased gastric mucosal non-protein SH concentration found at a progressed stage of the gastric mucosal lesions. These results indicate that TJ-15 exerts a therapeutic effect on WIR stress-induced acute gastric lesions in rats more strongly than TJ-10 or TJ-35, and suggest that the therapeutic effect of TJ-15 could be due to its preventive actions on lipid peroxidation and sulphydryl oxidation via oxygen free radicals generated by the xanthine-XO system and infiltrated neutrophils in the gastric mucosa and on neutrophil infiltration into the tissue.

Original languageEnglish
Pages (from-to)588-592
Number of pages5
JournalPhytotherapy Research
Volume13
Issue number7
DOIs
Publication statusPublished - 11-1999

All Science Journal Classification (ASJC) codes

  • Pharmacology

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