Effects of chronic depletion of high-energy phosphate compounds by feeding β-guanidinopropionic acid (β-GPA) with or without hindlimb suspension (HS) on body temperature were studied in rats. Lower rectal and skin temperatures were observed in rats after 10 d of HS. Suspension-related enlargement of the interscapular brown adipose tissue (BAT), associated with adrenal hypertrophy, was seen. Feeding β-GPA also caused a hypothermia and BAT enlargement. It is suggested that the hypothermic response to HS may be due to decreased contractile activity and metabolic rate in skeletal muscles, associated with stress. It is also speculated that the changes in the thermogenesis in rats fed β-GPA might be related to a stimulated ATP synthesis with sacrificed heat production, but not associated with stress.
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