Three cases of Kimura's disease

K. Yoneda, T. Nakajima, Y. Yoshimura, M. Kobayashi, T. Nishiyama

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The characteristic clinical sign leading to a diagnosis of Kimura's disease (eosinophilic granulomatosis of the soft tissue) is the presence of a subcutaneous mass, usually in the region of the head and neck, which can be confirmed on a histological examination of this tissue. Although many ways of treating this disease have been reported, a definitive method has not yet been established. A surgical excision or radiation and steroid therapy have been the primary ways. However, any one of these methods used independently has led to a high incidence of recurrence. In this report, the authors discuss three cases of Kimura's disease and describe their method of treatment, using a form of combined therapy. Surgery is performed to reduce the size of the tumor mass, and depending on the amount of the peripheral eosinophiles, additional steroid and/or radiation treatment is also carried out. Of cases so treated, the longest observation period after surgery has been 5 years, and there have been no instances of a recurrence of the tumor. As a result of our experience, we feel that a combined therapy is useful for treating Kumura's disease, and that additional therapy is heeded to suppress eosinophilic production so as to prevent tumor regrowth.

Original languageEnglish
Pages (from-to)1071-1078
Number of pages8
JournalJapanese Journal of Plastic and Reconstructive Surgery
Issue number10
Publication statusPublished - 1989

All Science Journal Classification (ASJC) codes

  • Surgery


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