Three-dimensional airway lumen volumetry: Comparison with bronchial wall area and parenchymal densitometry in assessment of airway obstruction in pulmonary emphysema

Hisanobu Koyama, Y. Ohno, M. Nishio, D. Takenaka, T. Yoshikawa, S. Matsumoto, Y. Nishimura, K. Sugimura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: The purpose of this study was to compare three-dimensional airway lumen volumetry with bronchial wall area and parenchymal densitometry in the assessment of airway obstruction in pulmonary emphysema. Methods: 56 patients, who were smokers, underwent CT examination and pulmonary function tests (PFTs). For quantitative assessments, the following parameters were computationally calculated: (1) percentage of voxels 2950, 2960 and -970 HU in the lung (%LAA-950, %LAA-960 and %LAA-970, respectively); (2) percentage of partial bronchi luminal volumes per total luminal volumes (LVmain, main and distal bronchial volume/total luminal volume; LVlobe, lobar and distal bronchial volume/total luminal volume); and (3) mean wall area percentages of segmental bronchi of the right apical and left apicoposterior segment (WA%seg) and of subsegmental bronchi (WA%sub) in the upper lobes. These parameters were correlated with PFTs and statistically compared between a chronic obstructive pulmonary disease (COPD) group [forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)<70] and a non-COPD group. Results: FEV1, maximum mid-expiratory flow rate and forced expiratory flow at 25% vital capacity had significant correlation with LVmain (r>0.53, p<0.0001), LVlobe (r>0.52, p<0.0001), WA%seg (|r|>0.29, p<0.05) and WA%sub (|r|>0.31, p<0.05). FEV1/FVC had significant correlation with all parameters (0.27,|r|<0.52, p<0.05). LVmain and LVlobe and WA%seg and WA% sub were significantly different between the two groups (LV main and LVlobe; p<0.0001, WA%seg and WA%sub; p<0.05). Conclusions: Bronchial luminal volumetric assessment better reflected the airflow limitation parameters. Advances in knowledge: Bronchial luminal volumetric assessment can potentially be used to gauge airflow limitation in pulmonary emphysema.

Original languageEnglish
Pages (from-to)1525-1532
Number of pages8
JournalBritish Journal of Radiology
Volume85
Issue number1020
DOIs
Publication statusPublished - 01-12-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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