Three-dimensional computed tomographic volumetric changes in pancreas before and after living donor surgery for pancreas transplantation

Effect of volume on glucose metabolism

K. Otsuki, N. Akutsu, M. Maruyama, K. Saigo, M. Hasegawa, H. Aoyama, I. Matsumoto, T. Asano, Taihei Ito, Takashi Kenmochi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the present study, we aimed to compare the pancreas volumetric changes before and after living donor surgery for pancreas transplantation, using three-dimensional (3D) computed tomography (CT) and glucose metabolism. Pancreatic volume (PV) measurement using 3D CT was performed in 13 consecutive donors who underwent distal pancreatectomy for simultaneous living donor pancreas and kidney transplantation. PV was measured using a workstation before and 3 months after living donor operation. As the parameters of glucose metabolism, hemoglobin A1c (HbA1c) level, fasting plasma glucose (FPG) level, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), and insulinogenic index (IGI) were examined simultaneously with the PV measurement. The preoperative and postoperative PVs of pancreas was 30 ± 5 mL and 42 ± 9 mL, respectively. The postoperative PV was significantly higher than the preoperative PV (P <.01) and increased by approximately 40% at 3 months after surgery. The postoperative FPG and HbA1c levels were significantly higher than the preoperative values (P <.01). BMI decreased significantly after surgery (P <.01). No differences in HOMA-IR and IGI were noted between before and after surgery. Diabetes mellitus was not observed any of the 13 living donors during this period. Distal pancreatectomy for living donors caused an increase in the PV and maintained insulin resistance, but it was not sufficient to maintain glucose metabolism at the preoperative state.

Original languageEnglish
Pages (from-to)963-966
Number of pages4
JournalTransplantation Proceedings
Volume46
Issue number3
DOIs
Publication statusPublished - 01-01-2014

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Pancreas Transplantation
Living Donors
Pancreas
Glucose
Insulin Resistance
Pancreatectomy
Fasting
Hemoglobins
Body Mass Index
Homeostasis
Tomography
Kidney Transplantation
Diabetes Mellitus
Tissue Donors

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

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title = "Three-dimensional computed tomographic volumetric changes in pancreas before and after living donor surgery for pancreas transplantation: Effect of volume on glucose metabolism",
abstract = "In the present study, we aimed to compare the pancreas volumetric changes before and after living donor surgery for pancreas transplantation, using three-dimensional (3D) computed tomography (CT) and glucose metabolism. Pancreatic volume (PV) measurement using 3D CT was performed in 13 consecutive donors who underwent distal pancreatectomy for simultaneous living donor pancreas and kidney transplantation. PV was measured using a workstation before and 3 months after living donor operation. As the parameters of glucose metabolism, hemoglobin A1c (HbA1c) level, fasting plasma glucose (FPG) level, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), and insulinogenic index (IGI) were examined simultaneously with the PV measurement. The preoperative and postoperative PVs of pancreas was 30 ± 5 mL and 42 ± 9 mL, respectively. The postoperative PV was significantly higher than the preoperative PV (P <.01) and increased by approximately 40{\%} at 3 months after surgery. The postoperative FPG and HbA1c levels were significantly higher than the preoperative values (P <.01). BMI decreased significantly after surgery (P <.01). No differences in HOMA-IR and IGI were noted between before and after surgery. Diabetes mellitus was not observed any of the 13 living donors during this period. Distal pancreatectomy for living donors caused an increase in the PV and maintained insulin resistance, but it was not sufficient to maintain glucose metabolism at the preoperative state.",
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Three-dimensional computed tomographic volumetric changes in pancreas before and after living donor surgery for pancreas transplantation : Effect of volume on glucose metabolism. / Otsuki, K.; Akutsu, N.; Maruyama, M.; Saigo, K.; Hasegawa, M.; Aoyama, H.; Matsumoto, I.; Asano, T.; Ito, Taihei; Kenmochi, Takashi.

In: Transplantation Proceedings, Vol. 46, No. 3, 01.01.2014, p. 963-966.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Three-dimensional computed tomographic volumetric changes in pancreas before and after living donor surgery for pancreas transplantation

T2 - Effect of volume on glucose metabolism

AU - Otsuki, K.

AU - Akutsu, N.

AU - Maruyama, M.

AU - Saigo, K.

AU - Hasegawa, M.

AU - Aoyama, H.

AU - Matsumoto, I.

AU - Asano, T.

AU - Ito, Taihei

AU - Kenmochi, Takashi

PY - 2014/1/1

Y1 - 2014/1/1

N2 - In the present study, we aimed to compare the pancreas volumetric changes before and after living donor surgery for pancreas transplantation, using three-dimensional (3D) computed tomography (CT) and glucose metabolism. Pancreatic volume (PV) measurement using 3D CT was performed in 13 consecutive donors who underwent distal pancreatectomy for simultaneous living donor pancreas and kidney transplantation. PV was measured using a workstation before and 3 months after living donor operation. As the parameters of glucose metabolism, hemoglobin A1c (HbA1c) level, fasting plasma glucose (FPG) level, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), and insulinogenic index (IGI) were examined simultaneously with the PV measurement. The preoperative and postoperative PVs of pancreas was 30 ± 5 mL and 42 ± 9 mL, respectively. The postoperative PV was significantly higher than the preoperative PV (P <.01) and increased by approximately 40% at 3 months after surgery. The postoperative FPG and HbA1c levels were significantly higher than the preoperative values (P <.01). BMI decreased significantly after surgery (P <.01). No differences in HOMA-IR and IGI were noted between before and after surgery. Diabetes mellitus was not observed any of the 13 living donors during this period. Distal pancreatectomy for living donors caused an increase in the PV and maintained insulin resistance, but it was not sufficient to maintain glucose metabolism at the preoperative state.

AB - In the present study, we aimed to compare the pancreas volumetric changes before and after living donor surgery for pancreas transplantation, using three-dimensional (3D) computed tomography (CT) and glucose metabolism. Pancreatic volume (PV) measurement using 3D CT was performed in 13 consecutive donors who underwent distal pancreatectomy for simultaneous living donor pancreas and kidney transplantation. PV was measured using a workstation before and 3 months after living donor operation. As the parameters of glucose metabolism, hemoglobin A1c (HbA1c) level, fasting plasma glucose (FPG) level, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), and insulinogenic index (IGI) were examined simultaneously with the PV measurement. The preoperative and postoperative PVs of pancreas was 30 ± 5 mL and 42 ± 9 mL, respectively. The postoperative PV was significantly higher than the preoperative PV (P <.01) and increased by approximately 40% at 3 months after surgery. The postoperative FPG and HbA1c levels were significantly higher than the preoperative values (P <.01). BMI decreased significantly after surgery (P <.01). No differences in HOMA-IR and IGI were noted between before and after surgery. Diabetes mellitus was not observed any of the 13 living donors during this period. Distal pancreatectomy for living donors caused an increase in the PV and maintained insulin resistance, but it was not sufficient to maintain glucose metabolism at the preoperative state.

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M3 - Article

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JF - Transplantation Proceedings

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