Three-year prognosis of Japanese patients with ST-elevation myocardial infarction treated with sirolimus-eluting stents

Daiji Yoshikawa, Satoshi Isobe, Hisashi Umeda, Tomoko Kawai, Takeshi Shimizu, Kentaro Yamashita, Hideki Ishii, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

OBJECTIVES: The long-term prognosis of Japanese ST-elevation myocardial infarction (STEMI) patients treated with sirolimus-eluting stents (SESs) still remains unclear. We aimed to determine the 3-year outcomes of this population. METHODS AND RESULTS: Major adverse cardiac events (MACE) defined as all-cause death, reinfarction, and target vessel revascularization during 3 years, angiographic data, and events of stent thrombosis were compared between 95 consecutive STEMI patients treated with SESs and 94 treated with bare-metal stents (BMSs). Significant advantages were discerned in all follow-up angiographic data from the SES group. The rate of target vessel revascularization was significantly less in the SES group than in the BMS group (P=0.006). There was no significant difference in the rates of mortality (P=0.258) or reinfarction (P=0.496). The Kaplan-Meier analysis showed that at a 3-year follow-up, MACE-free survival was significantly higher in the SES group than in the BMS group (log-rank P<0.001). Academic Research Consortium 'definite' or 'probable' stent thrombosis was observed in two patients ('early' and 'very late') in the SES group and no patient in the BMS group. We observed no significant difference in the event rates of stent thrombosis (2.1% SES group vs. 0% BMS group, P=0.497). CONCLUSION: In Japanese STEMI patients, a 3-year follow-up showed that the routine use of SESs reduces the incidence of MACE without increasing the risk of stent thrombosis.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalCoronary Artery Disease
Volume20
Issue number6
DOIs
Publication statusPublished - 09-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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