Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report

Naomi Kajita, Yoshinao Muro, Akihiro Tomita, Kanji Hirashima, Tadashi Matsushita, Tomoki Naoe, Yasushi Tomita

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2 Citations (Scopus)


We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalJapanese Journal of Allergology
Issue number5
Publication statusPublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy


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