Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report

Naomi Kajita; Yoshinao Muro; Akihiro Tomita; Kanji Hirashima; Tadashi Matsushita; Tomoki Naoe; Yasushi Tomita

Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report

Naomi Kajita, Yoshinao Muro, Akihiro Tomita, Kanji Hirashima, Tadashi Matsushita, Tomoki Naoe, Yasushi Tomita

Research output: Contribution to journal › Article › peer-review

Abstract

We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.

Original language	English
Pages (from-to)	567-572
Number of pages	6
Journal	Japanese Journal of Allergology
Volume	58
Issue number	5
Publication status	Published - 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy

Cite this

@article{4c6295becda3404e90e44e7b5f0b0c72,

title = "Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report",

abstract = "We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.",

author = "Naomi Kajita and Yoshinao Muro and Akihiro Tomita and Kanji Hirashima and Tadashi Matsushita and Tomoki Naoe and Yasushi Tomita",

year = "2009",

language = "English",

volume = "58",

pages = "567--572",

journal = "Japanese Journal of Allergology",

issn = "0021-4884",

publisher = "Japanese Society of Allergology",

number = "5",

}

TY - JOUR

T1 - Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report

AU - Kajita, Naomi

AU - Muro, Yoshinao

AU - Tomita, Akihiro

AU - Hirashima, Kanji

AU - Matsushita, Tadashi

AU - Naoe, Tomoki

AU - Tomita, Yasushi

PY - 2009

Y1 - 2009

N2 - We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.

AB - We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.

UR - http://www.scopus.com/inward/record.url?scp=67650822983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650822983&partnerID=8YFLogxK

M3 - Article

C2 - 19487839

AN - SCOPUS:67650822983

SN - 0021-4884

VL - 58

SP - 567

EP - 572

JO - Japanese Journal of Allergology

JF - Japanese Journal of Allergology

IS - 5

ER -

Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this