Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report

Naomi Kajita, Yoshinao Muro, Akihiro Tomita, Kanji Hirashima, Tadashi Matsushita, Tomoki Naoe, Yasushi Tomita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalJapanese Journal of Allergology
Volume58
Issue number5
Publication statusPublished - 27-07-2009
Externally publishedYes

Fingerprint

Mixed Connective Tissue Disease
Thrombotic Thrombocytopenic Purpura
Thrombospondins
Disintegrins
Raynaud Disease
Plasma Exchange
Hemolytic Anemia
Hematologic Tests
Metalloproteases
Prednisolone
Thrombocytopenia
Fingers
Oral Administration
Recurrence
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Kajita, N., Muro, Y., Tomita, A., Hirashima, K., Matsushita, T., Naoe, T., & Tomita, Y. (2009). Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report. Japanese Journal of Allergology, 58(5), 567-572.
Kajita, Naomi ; Muro, Yoshinao ; Tomita, Akihiro ; Hirashima, Kanji ; Matsushita, Tadashi ; Naoe, Tomoki ; Tomita, Yasushi. / Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report. In: Japanese Journal of Allergology. 2009 ; Vol. 58, No. 5. pp. 567-572.
@article{4c6295becda3404e90e44e7b5f0b0c72,
title = "Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report",
abstract = "We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.",
author = "Naomi Kajita and Yoshinao Muro and Akihiro Tomita and Kanji Hirashima and Tadashi Matsushita and Tomoki Naoe and Yasushi Tomita",
year = "2009",
month = "7",
day = "27",
language = "English",
volume = "58",
pages = "567--572",
journal = "Japanese Journal of Allergology",
issn = "0021-4884",
publisher = "Japanese Society of Allergology",
number = "5",

}

Kajita, N, Muro, Y, Tomita, A, Hirashima, K, Matsushita, T, Naoe, T & Tomita, Y 2009, 'Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report', Japanese Journal of Allergology, vol. 58, no. 5, pp. 567-572.

Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report. / Kajita, Naomi; Muro, Yoshinao; Tomita, Akihiro; Hirashima, Kanji; Matsushita, Tadashi; Naoe, Tomoki; Tomita, Yasushi.

In: Japanese Journal of Allergology, Vol. 58, No. 5, 27.07.2009, p. 567-572.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report

AU - Kajita, Naomi

AU - Muro, Yoshinao

AU - Tomita, Akihiro

AU - Hirashima, Kanji

AU - Matsushita, Tadashi

AU - Naoe, Tomoki

AU - Tomita, Yasushi

PY - 2009/7/27

Y1 - 2009/7/27

N2 - We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.

AB - We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin typel motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.

UR - http://www.scopus.com/inward/record.url?scp=67650822983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650822983&partnerID=8YFLogxK

M3 - Article

C2 - 19487839

AN - SCOPUS:67650822983

VL - 58

SP - 567

EP - 572

JO - Japanese Journal of Allergology

JF - Japanese Journal of Allergology

SN - 0021-4884

IS - 5

ER -

Kajita N, Muro Y, Tomita A, Hirashima K, Matsushita T, Naoe T et al. Thrombotic thrombocytopenic purpura with mixed connective tissue disease. A case report. Japanese Journal of Allergology. 2009 Jul 27;58(5):567-572.