TY - JOUR
T1 - Thymic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
T2 - A gene methylation study
AU - Takino, Hisashi
AU - Li, Chunmei
AU - Yamada, Seiji
AU - Sato, Fumihiko
AU - Masaki, Ayako
AU - Fujiyoshi, Yukio
AU - Hattori, Hideo
AU - Inagaki, Hiroshi
PY - 2013/8
Y1 - 2013/8
N2 - Although rare, thymic mucosa-associated lymphoid tissue (MALT) lymphoma is considered to be a distinct clinicopathological entity. Using a methylation-specific polymerase chain reaction, we analyzed thymic MALT lymphomas (n = 18) for their methylation of the following seven tumor suppressor genes: DAPK1, p16INK4A, p14ARF, CDH1, RARB, TIMP3 and MGMT. Reactive lymph nodes (n = 16) were used as a control. Of the seven genes examined, thymic MALT lymphomas had an increased number of genes that were methylated (2.9 genes) as compared with reactive lymph nodes (0.63, p = 0.0003). In particular, thymic MALT lymphomas showed a frequent methylation of DAPK1, CDH1, TIMP3 and p14ARF. In addition, gene methylation of p14 ARF was associated with a larger tumor size, while that of the other three genes was not associated with any clinicopathological features examined. This study suggests that methylation of tumor suppressor genes may play an important role in thymic MALT lymphoma.
AB - Although rare, thymic mucosa-associated lymphoid tissue (MALT) lymphoma is considered to be a distinct clinicopathological entity. Using a methylation-specific polymerase chain reaction, we analyzed thymic MALT lymphomas (n = 18) for their methylation of the following seven tumor suppressor genes: DAPK1, p16INK4A, p14ARF, CDH1, RARB, TIMP3 and MGMT. Reactive lymph nodes (n = 16) were used as a control. Of the seven genes examined, thymic MALT lymphomas had an increased number of genes that were methylated (2.9 genes) as compared with reactive lymph nodes (0.63, p = 0.0003). In particular, thymic MALT lymphomas showed a frequent methylation of DAPK1, CDH1, TIMP3 and p14ARF. In addition, gene methylation of p14 ARF was associated with a larger tumor size, while that of the other three genes was not associated with any clinicopathological features examined. This study suggests that methylation of tumor suppressor genes may play an important role in thymic MALT lymphoma.
KW - Clinicopathological analysis
KW - Gene methylation
KW - Thymic MALT lymphoma
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U2 - 10.3109/10428194.2013.765563
DO - 10.3109/10428194.2013.765563
M3 - Article
C2 - 23320886
AN - SCOPUS:84880310692
SN - 1042-8194
VL - 54
SP - 1742
EP - 1746
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 8
ER -
