Thymic microenvironments, 3-D versus 2-D?

Willem Van Ewijk, Bao Ping Wang, Georg Holländer, Hiroshi Kawamoto, Eugenia Spanopoulou, Manami Itoi, Takashi Amagai, Yu Fei Jiang, Wilfred T.V. Germeraad, Wei Fung Chen, Yoshimoto Katsura

Research output: Contribution to journalArticlepeer-review

114 Citations (Scopus)

Abstract

Lympho-stromal interactions in the thymus crucially determine the fate of developing T cells. Epithelial cells, inter-digitating reticular cells, macrophages and fibroblasts all play a role in the shaping of the T cell repertoire. Recently published evidence shows that lympho-stromal interaction acts bi-directional. Developing T cells themselves, at different stages of differentiation, control the microarchitecture of thymic microenvironments, a phenomenon designated as 'crosstalk'. This paper reviews experiments showing that developing T cells crosstalk to different thymic epithelial cells in a stepwise fashion. In this way, correctly organized thymic microenvironments guarantee normal thymopoiesis.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalSeminars in Immunology
Volume11
Issue number1
DOIs
Publication statusPublished - 01-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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