Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease

Satomi Mugii, Hiroyuki Hanada, Manabu Okubo, Daisaku Masuda, Keiko Takeoka, Yoh Hidaka, Tohru Ohama, Akifumi Matsuyama, Yumiko Nakagawa-Toyama, Makoto Nishida, Masato Ishigami, Issei Komuro, Shizuya Yamashita

Research output: Contribution to journalArticle

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Abstract

Aim: Apolipoprotein B-48 (apoB-48) is a major apolipoprotein of intestine-derived chylomicrons (CM) and CM remnants (CMR). Clinically overt hypothyroidism (OH) has been associated with premature and accelerated coronary atherosclerosis. To clarify the clinical significance of apoB-48 measurement in patients with thyroid disease, we investigated the correlations between the serum apoB-48 level and thyroid hormones. Methods: From outpatients of Osaka University Hospital, patients with OH, subjects with subclinical hypothyroidism (SH) and subjects with normal thyroid function were collected and analyzed by measuring serum TSH, FT4 and FT3 levels. Serum apoB-48 levels were measured by a chemiluminescence enzyme immunoassay and the correlations with thyroid hormone levels or lipid profiles were assessed. These levels were compared among subjects with OH, SH and healthy controls. Results: Serum apoB-48 level was correlated with TSH, total cholesterol (TC) and triglycerides (TG), but negatively with FT4 and FT3 level. LDL-C and HDL-C levels were not correlated with serum apoB-48 levels. Serum apoB-48 in patients with OH (7.4±5.9 μg/mL) was significantly higher than in those with hyperthyroidism (5.1±3.5 μg/mL; p<0.01) and normal subjects (4.7±3.7 μg/mL; p<0.01), but decreased after levo-thyroxine replacement. ApoB-48, TG and TSH were significantly higher in SH subjects than normal subjects, suggesting that serum apoB-48 level depends on the thyroid function status, similar to TC, LDL-C and TG. Conclusion: Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state.

Original languageEnglish
Pages (from-to)891-896
Number of pages6
JournalJournal of Atherosclerosis and Thrombosis
Volume19
Issue number10
Publication statusPublished - 19-11-2012

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Apolipoprotein B-48
Thyroid Diseases
Thyroid Gland
Hypothyroidism
Serum
Triglycerides
Thyroid Hormones
Coronary Artery Disease
Chylomicron Remnants
Cholesterol
Chylomicrons
Chemiluminescence
Apolipoproteins
Hyperthyroidism
Luminescence
Immunoenzyme Techniques
Thyroxine
LDL Cholesterol
Intestines
Atherosclerosis

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Mugii, S., Hanada, H., Okubo, M., Masuda, D., Takeoka, K., Hidaka, Y., ... Yamashita, S. (2012). Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease. Journal of Atherosclerosis and Thrombosis, 19(10), 891-896.
Mugii, Satomi ; Hanada, Hiroyuki ; Okubo, Manabu ; Masuda, Daisaku ; Takeoka, Keiko ; Hidaka, Yoh ; Ohama, Tohru ; Matsuyama, Akifumi ; Nakagawa-Toyama, Yumiko ; Nishida, Makoto ; Ishigami, Masato ; Komuro, Issei ; Yamashita, Shizuya. / Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease. In: Journal of Atherosclerosis and Thrombosis. 2012 ; Vol. 19, No. 10. pp. 891-896.
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abstract = "Aim: Apolipoprotein B-48 (apoB-48) is a major apolipoprotein of intestine-derived chylomicrons (CM) and CM remnants (CMR). Clinically overt hypothyroidism (OH) has been associated with premature and accelerated coronary atherosclerosis. To clarify the clinical significance of apoB-48 measurement in patients with thyroid disease, we investigated the correlations between the serum apoB-48 level and thyroid hormones. Methods: From outpatients of Osaka University Hospital, patients with OH, subjects with subclinical hypothyroidism (SH) and subjects with normal thyroid function were collected and analyzed by measuring serum TSH, FT4 and FT3 levels. Serum apoB-48 levels were measured by a chemiluminescence enzyme immunoassay and the correlations with thyroid hormone levels or lipid profiles were assessed. These levels were compared among subjects with OH, SH and healthy controls. Results: Serum apoB-48 level was correlated with TSH, total cholesterol (TC) and triglycerides (TG), but negatively with FT4 and FT3 level. LDL-C and HDL-C levels were not correlated with serum apoB-48 levels. Serum apoB-48 in patients with OH (7.4±5.9 μg/mL) was significantly higher than in those with hyperthyroidism (5.1±3.5 μg/mL; p<0.01) and normal subjects (4.7±3.7 μg/mL; p<0.01), but decreased after levo-thyroxine replacement. ApoB-48, TG and TSH were significantly higher in SH subjects than normal subjects, suggesting that serum apoB-48 level depends on the thyroid function status, similar to TC, LDL-C and TG. Conclusion: Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state.",
author = "Satomi Mugii and Hiroyuki Hanada and Manabu Okubo and Daisaku Masuda and Keiko Takeoka and Yoh Hidaka and Tohru Ohama and Akifumi Matsuyama and Yumiko Nakagawa-Toyama and Makoto Nishida and Masato Ishigami and Issei Komuro and Shizuya Yamashita",
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Mugii, S, Hanada, H, Okubo, M, Masuda, D, Takeoka, K, Hidaka, Y, Ohama, T, Matsuyama, A, Nakagawa-Toyama, Y, Nishida, M, Ishigami, M, Komuro, I & Yamashita, S 2012, 'Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease', Journal of Atherosclerosis and Thrombosis, vol. 19, no. 10, pp. 891-896.

Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease. / Mugii, Satomi; Hanada, Hiroyuki; Okubo, Manabu; Masuda, Daisaku; Takeoka, Keiko; Hidaka, Yoh; Ohama, Tohru; Matsuyama, Akifumi; Nakagawa-Toyama, Yumiko; Nishida, Makoto; Ishigami, Masato; Komuro, Issei; Yamashita, Shizuya.

In: Journal of Atherosclerosis and Thrombosis, Vol. 19, No. 10, 19.11.2012, p. 891-896.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease

AU - Mugii, Satomi

AU - Hanada, Hiroyuki

AU - Okubo, Manabu

AU - Masuda, Daisaku

AU - Takeoka, Keiko

AU - Hidaka, Yoh

AU - Ohama, Tohru

AU - Matsuyama, Akifumi

AU - Nakagawa-Toyama, Yumiko

AU - Nishida, Makoto

AU - Ishigami, Masato

AU - Komuro, Issei

AU - Yamashita, Shizuya

PY - 2012/11/19

Y1 - 2012/11/19

N2 - Aim: Apolipoprotein B-48 (apoB-48) is a major apolipoprotein of intestine-derived chylomicrons (CM) and CM remnants (CMR). Clinically overt hypothyroidism (OH) has been associated with premature and accelerated coronary atherosclerosis. To clarify the clinical significance of apoB-48 measurement in patients with thyroid disease, we investigated the correlations between the serum apoB-48 level and thyroid hormones. Methods: From outpatients of Osaka University Hospital, patients with OH, subjects with subclinical hypothyroidism (SH) and subjects with normal thyroid function were collected and analyzed by measuring serum TSH, FT4 and FT3 levels. Serum apoB-48 levels were measured by a chemiluminescence enzyme immunoassay and the correlations with thyroid hormone levels or lipid profiles were assessed. These levels were compared among subjects with OH, SH and healthy controls. Results: Serum apoB-48 level was correlated with TSH, total cholesterol (TC) and triglycerides (TG), but negatively with FT4 and FT3 level. LDL-C and HDL-C levels were not correlated with serum apoB-48 levels. Serum apoB-48 in patients with OH (7.4±5.9 μg/mL) was significantly higher than in those with hyperthyroidism (5.1±3.5 μg/mL; p<0.01) and normal subjects (4.7±3.7 μg/mL; p<0.01), but decreased after levo-thyroxine replacement. ApoB-48, TG and TSH were significantly higher in SH subjects than normal subjects, suggesting that serum apoB-48 level depends on the thyroid function status, similar to TC, LDL-C and TG. Conclusion: Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state.

AB - Aim: Apolipoprotein B-48 (apoB-48) is a major apolipoprotein of intestine-derived chylomicrons (CM) and CM remnants (CMR). Clinically overt hypothyroidism (OH) has been associated with premature and accelerated coronary atherosclerosis. To clarify the clinical significance of apoB-48 measurement in patients with thyroid disease, we investigated the correlations between the serum apoB-48 level and thyroid hormones. Methods: From outpatients of Osaka University Hospital, patients with OH, subjects with subclinical hypothyroidism (SH) and subjects with normal thyroid function were collected and analyzed by measuring serum TSH, FT4 and FT3 levels. Serum apoB-48 levels were measured by a chemiluminescence enzyme immunoassay and the correlations with thyroid hormone levels or lipid profiles were assessed. These levels were compared among subjects with OH, SH and healthy controls. Results: Serum apoB-48 level was correlated with TSH, total cholesterol (TC) and triglycerides (TG), but negatively with FT4 and FT3 level. LDL-C and HDL-C levels were not correlated with serum apoB-48 levels. Serum apoB-48 in patients with OH (7.4±5.9 μg/mL) was significantly higher than in those with hyperthyroidism (5.1±3.5 μg/mL; p<0.01) and normal subjects (4.7±3.7 μg/mL; p<0.01), but decreased after levo-thyroxine replacement. ApoB-48, TG and TSH were significantly higher in SH subjects than normal subjects, suggesting that serum apoB-48 level depends on the thyroid function status, similar to TC, LDL-C and TG. Conclusion: Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state.

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Mugii S, Hanada H, Okubo M, Masuda D, Takeoka K, Hidaka Y et al. Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease. Journal of Atherosclerosis and Thrombosis. 2012 Nov 19;19(10):891-896.