Time course characteristics of human herpesvirus 6 specific cellular immune response and natural killer cell activity in patients with exanthema subitum

Takuji Kumagai, Tetsushi Yoshikawa, Mariko Yoshida, Toyo Okui, Masana Ihira, Nobuo Nagata, Shoki Yano, Kimiyasu Shiraki, Masao Yamada, Kiyoshi Ichihara, Yoshizo Asano

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The time-course of cell-mediated immunity in exanthema subitum is not well documented. The lymphoproliferative response to purified human herpesvirus 6 (HHV-6) antigen and to phytohemagglutinin was measured and natural killer (NK) cell activities determined in three consecutive specimens obtained biweekly from 18 young children and infants with exanthema subitum. Virus isolation and PCR detection of virus DNA and determination of neutralization antibody to HHV-6 and -7 were also carried out. The magnitude of the HHV-6 specific lymphoproliferative response varied; however, in most cases the time course kinetics revealed a low response in the acute phase with a subsequent gradual increase. In contrast, NK cell activities were high in the acute phase and declined gradually during convalescence. The lymphoproliferative response to phytohemagglutinin did not show a consistent trend in kinetics of time; however, dynamic changes in activity were observed in patients during the acute and convalescent periods. The results suggest that NK cells play a major role in resolving acute phase infection while specific lymphocyte activity develops later. The cause of the delayed development of HHV-6 specific lymphoproliferative response is unknown. The lymphoproliferative response to phytohemagglutinin ratios implied that HHV-6 infection has some impact on host T-cell immunity during the course of exanthema subitum.

Original languageEnglish
Pages (from-to)792-799
Number of pages8
JournalJournal of Medical Virology
Volume78
Issue number6
DOIs
Publication statusPublished - 06-2006

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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