Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3): A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study

Kenji Wakai, Koji Suzuki, Yoshinori Ito, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Koji Tamakoshi, Shinkan TokudomeShuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

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Abstract

The preventive effects of physical activity against cancer may partly be ascribable to a possible decrease in insulin-like growth factor-I (IGF-I) induced by the activity. To examine the association of physical activity with IGF-I and IGF-binding protein-3 (IGFBP-3), we analyzed the data for control participants in a case-control study nested in the Japan Collaborative Cohort Study. A total of 3,598 men and 3,359 women throughout Japan, aged 40 to 79 years, were administered a lifestyle questionnaire and provided serum samples. The age- and body mass index (BMI)- adjusted serum levels of IGF-I and IGFBP-3 were lower among those who walked for longer times with a significant trend in both sexes (trend P < 0.01). Among participants who walked one hour or more per day, the mean levels of serum IGF-I and IGFBP-3 were 138.7 ng/ml and 2.87 μg/ml in men and 125.7 ng/ml and 3.14 μg/ml in women, respectively. The corresponding figures among those rarely walked were 147.4 ng/ml and 2.99 μg/ml in men and 132.3 ng/ml and 3.21 μg/ml in women. For IGF-I, adjustment for serum IGFBP-3 did not essentially alter such associations although the trend in women did not reach statistical significance. A decreased level of serum IGF-I was associated with longer exercise time in men even after adjustment for serum IGFBP-3 (trend P = 0.033 after adjustment for age, BMI, and serum IGFBP-3), whereas the time was positively correlated with serum IGF-I in women (trend P = 0.048). Our findings may partly explain the protective effects of physical activity against several sites of cancer.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 05-12-2009

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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    Wakai, K., Suzuki, K., Ito, Y., Watanabe, Y., Inaba, Y., Tajima, K., Nakachi, K., Tamakoshi, A., Mori, M., Sakauchi, F., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Kurosawa, M., Hoshiyama, Y., Tanabe, N., Tamakoshi, K., ... Shio, H. (2009). Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3): A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study. Asian Pacific Journal of Cancer Prevention, 10(SUPPL.1), 23-28.