Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3)

A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study

Kenji Wakai, Koji Suzuki, Yoshinori Ito, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Koji Tamakoshi, Shinkan Tokudome & 15 others Shuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The preventive effects of physical activity against cancer may partly be ascribable to a possible decrease in insulin-like growth factor-I (IGF-I) induced by the activity. To examine the association of physical activity with IGF-I and IGF-binding protein-3 (IGFBP-3), we analyzed the data for control participants in a case-control study nested in the Japan Collaborative Cohort Study. A total of 3,598 men and 3,359 women throughout Japan, aged 40 to 79 years, were administered a lifestyle questionnaire and provided serum samples. The age- and body mass index (BMI)- adjusted serum levels of IGF-I and IGFBP-3 were lower among those who walked for longer times with a significant trend in both sexes (trend P < 0.01). Among participants who walked one hour or more per day, the mean levels of serum IGF-I and IGFBP-3 were 138.7 ng/ml and 2.87 μg/ml in men and 125.7 ng/ml and 3.14 μg/ml in women, respectively. The corresponding figures among those rarely walked were 147.4 ng/ml and 2.99 μg/ml in men and 132.3 ng/ml and 3.21 μg/ml in women. For IGF-I, adjustment for serum IGFBP-3 did not essentially alter such associations although the trend in women did not reach statistical significance. A decreased level of serum IGF-I was associated with longer exercise time in men even after adjustment for serum IGFBP-3 (trend P = 0.033 after adjustment for age, BMI, and serum IGFBP-3), whereas the time was positively correlated with serum IGF-I in women (trend P = 0.048). Our findings may partly explain the protective effects of physical activity against several sites of cancer.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 05-12-2009

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Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Walking
Japan
Cohort Studies
Cross-Sectional Studies
Exercise
Blood Proteins
Serum
Body Mass Index
Case-Control Studies
Life Style
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Wakai, Kenji ; Suzuki, Koji ; Ito, Yoshinori ; Watanabe, Yoshiyuki ; Inaba, Yutaka ; Tajima, Kazuo ; Nakachi, Kei ; Tamakoshi, Akiko ; Mori, Mitsuru ; Sakauchi, Fumio ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Tamakoshi, Koji ; Tokudome, Shinkan ; Hashimoto, Shuji ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Yoshimura, Takesumi ; Fujino, Yoshihisa ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo. / Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3) : A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study. In: Asian Pacific Journal of Cancer Prevention. 2009 ; Vol. 10, No. SUPPL.1. pp. 23-28.
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title = "Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3): A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study",
abstract = "The preventive effects of physical activity against cancer may partly be ascribable to a possible decrease in insulin-like growth factor-I (IGF-I) induced by the activity. To examine the association of physical activity with IGF-I and IGF-binding protein-3 (IGFBP-3), we analyzed the data for control participants in a case-control study nested in the Japan Collaborative Cohort Study. A total of 3,598 men and 3,359 women throughout Japan, aged 40 to 79 years, were administered a lifestyle questionnaire and provided serum samples. The age- and body mass index (BMI)- adjusted serum levels of IGF-I and IGFBP-3 were lower among those who walked for longer times with a significant trend in both sexes (trend P < 0.01). Among participants who walked one hour or more per day, the mean levels of serum IGF-I and IGFBP-3 were 138.7 ng/ml and 2.87 μg/ml in men and 125.7 ng/ml and 3.14 μg/ml in women, respectively. The corresponding figures among those rarely walked were 147.4 ng/ml and 2.99 μg/ml in men and 132.3 ng/ml and 3.21 μg/ml in women. For IGF-I, adjustment for serum IGFBP-3 did not essentially alter such associations although the trend in women did not reach statistical significance. A decreased level of serum IGF-I was associated with longer exercise time in men even after adjustment for serum IGFBP-3 (trend P = 0.033 after adjustment for age, BMI, and serum IGFBP-3), whereas the time was positively correlated with serum IGF-I in women (trend P = 0.048). Our findings may partly explain the protective effects of physical activity against several sites of cancer.",
author = "Kenji Wakai and Koji Suzuki and Yoshinori Ito and Yoshiyuki Watanabe and Yutaka Inaba and Kazuo Tajima and Kei Nakachi and Akiko Tamakoshi and Mitsuru Mori and Fumio Sakauchi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Shinkan Tokudome and Shuji Hashimoto and Shogo Kikuchi and Yasuhiko Wada and Takashi Kawamura and Yoshiyuki Watanabe and Kotaro Ozasa and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Takesumi Yoshimura and Yoshihisa Fujino and Akira Shibata and Naoyuki Okamoto and Hideo Shio",
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journal = "Asian Pacific Journal of Cancer Prevention",
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Wakai, K, Suzuki, K, Ito, Y, Watanabe, Y, Inaba, Y, Tajima, K, Nakachi, K, Tamakoshi, A, Mori, M, Sakauchi, F, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Tamakoshi, K, Tokudome, S, Hashimoto, S, Kikuchi, S, Wada, Y, Kawamura, T, Watanabe, Y, Ozasa, K, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Yoshimura, T, Fujino, Y, Shibata, A, Okamoto, N & Shio, H 2009, 'Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3): A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study', Asian Pacific Journal of Cancer Prevention, vol. 10, no. SUPPL.1, pp. 23-28.

Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3) : A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study. / Wakai, Kenji; Suzuki, Koji; Ito, Yoshinori; Watanabe, Yoshiyuki; Inaba, Yutaka; Tajima, Kazuo; Nakachi, Kei; Tamakoshi, Akiko; Mori, Mitsuru; Sakauchi, Fumio; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Tamakoshi, Koji; Tokudome, Shinkan; Hashimoto, Shuji; Kikuchi, Shogo; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Yoshimura, Takesumi; Fujino, Yoshihisa; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo.

In: Asian Pacific Journal of Cancer Prevention, Vol. 10, No. SUPPL.1, 05.12.2009, p. 23-28.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3)

T2 - A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study

AU - Wakai, Kenji

AU - Suzuki, Koji

AU - Ito, Yoshinori

AU - Watanabe, Yoshiyuki

AU - Inaba, Yutaka

AU - Tajima, Kazuo

AU - Nakachi, Kei

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2009/12/5

Y1 - 2009/12/5

N2 - The preventive effects of physical activity against cancer may partly be ascribable to a possible decrease in insulin-like growth factor-I (IGF-I) induced by the activity. To examine the association of physical activity with IGF-I and IGF-binding protein-3 (IGFBP-3), we analyzed the data for control participants in a case-control study nested in the Japan Collaborative Cohort Study. A total of 3,598 men and 3,359 women throughout Japan, aged 40 to 79 years, were administered a lifestyle questionnaire and provided serum samples. The age- and body mass index (BMI)- adjusted serum levels of IGF-I and IGFBP-3 were lower among those who walked for longer times with a significant trend in both sexes (trend P < 0.01). Among participants who walked one hour or more per day, the mean levels of serum IGF-I and IGFBP-3 were 138.7 ng/ml and 2.87 μg/ml in men and 125.7 ng/ml and 3.14 μg/ml in women, respectively. The corresponding figures among those rarely walked were 147.4 ng/ml and 2.99 μg/ml in men and 132.3 ng/ml and 3.21 μg/ml in women. For IGF-I, adjustment for serum IGFBP-3 did not essentially alter such associations although the trend in women did not reach statistical significance. A decreased level of serum IGF-I was associated with longer exercise time in men even after adjustment for serum IGFBP-3 (trend P = 0.033 after adjustment for age, BMI, and serum IGFBP-3), whereas the time was positively correlated with serum IGF-I in women (trend P = 0.048). Our findings may partly explain the protective effects of physical activity against several sites of cancer.

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