Time to initiation of treatment with polymyxin B cartridge hemoperfusion in septic shock patients

Naoshi Takeyama, Hiroshi Noguchi, Akihiko Hirakawa, Hideki Kano, Kazuma Morino, Toru Obata, Tetsuya Sakamoto, Fumihiro Tamai, Hiroyasu Ishikura, Youichi Kase, Makoto Kobayashi, Toshio Naka, Yoshiki Takahashi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Background: We investigated whether early initiation of hemoperfusion with a polymyxin B cartridge (PMX) after the diagnosis of septic shock could improve the clinical outcome. Methods: A prospective, open-labeled, multicenter cohort study was performed at intensive care units in Japan. 41 patients received PMX within 6 h after the diagnosis of septic shock (early group) and 51 patients were treated after 6 h (late group). Results: The early group had a significantly shorter duration of ventilator support and also had a lower catecholamine requirement. PMX was effective for improvement of hypotension, hypoperfusion, the sequential organ failure assessment score, and pulmonary oxygenation regardless of the timing of its initiation. The 28-day mortality rate did not differ between the two groups. Conclusions: Early initiation of PMX shortened the duration of ventilator support and also reduced the catecholamine requirement, so early treatment of septic shock should achieve a better outcome.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalBlood Purification
Volume33
Issue number4
DOIs
Publication statusPublished - 06-2012

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

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