Timing of relapse and outcome after curative resection for colorectal cancer: A japanese multicenter study

Hirotoshi Kobayashi, Hidetaka Mochizuki, Takayuki Morita, Kenjiro Kotake, Tatsuo Teramoto, Shingo Kameoka, Yukio Saito, Keiichi Takahashi, Kazuo Hase, Masatoshi Ohya, Koutarou Maeda, Takashi Hirai, Masao Kameyama, Kazuo Shirouzu, Kenichi Sugihara

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The aim of this multicenter study was to clarify the influence of timing of relapse after curative resection for colorectal cancer on prognosis. Methods: We enrolled 5,230 consecutive patients who underwent curative resection for colorectal cancer at 14 hospitals from 1991 to 1996. All patients were intensively followed up. Time to relapse (TR) was classified into three groups as follows: group A, TR ≤1 year; group B, TR >1 year and ≤3 years, and group C, TR >3 years. The prognoses after relapse were compared among the three groups. Results: Of the 5,230 patients, 906 experienced relapse (17.3%). The curative resection rates for recurrent tumors were 35.2% in group A, 46.6% in group B, and 45.1% in group C (p = 0.0045). There were significant differences in the prognoses after relapse among the three TR groups in patients with relapse to the liver (p = 0.0175) and in those with local relapses (p = 0.0021), but not in those with pulmonary or anastomotic recurrence. There were no differences in prognoses after relapse in any recurrence site among the three groups in patients who underwent curative resection for relapse. Conclusion: If patients can undergo curative resection for relapse, they receive a survival benefit regardless of the timing of relapse.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalDigestive Surgery
Volume26
Issue number3
DOIs
Publication statusPublished - 01-07-2009

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

Fingerprint Dive into the research topics of 'Timing of relapse and outcome after curative resection for colorectal cancer: A japanese multicenter study'. Together they form a unique fingerprint.

  • Cite this

    Kobayashi, H., Mochizuki, H., Morita, T., Kotake, K., Teramoto, T., Kameoka, S., Saito, Y., Takahashi, K., Hase, K., Ohya, M., Maeda, K., Hirai, T., Kameyama, M., Shirouzu, K., & Sugihara, K. (2009). Timing of relapse and outcome after curative resection for colorectal cancer: A japanese multicenter study. Digestive Surgery, 26(3), 249-255. https://doi.org/10.1159/000226868