Tissue characterization of skin ulcer for bacterial infection by multiple statistical analysis of echo amplitude envelope

Masaaki Omura, Kenji Yoshida, Masushi Kohta, Takabumi Kubo, Toshimichi Ishiguro, Kazuto Kobayashi, Naohiro Hozumi, Tadashi Yamaguchi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

To characterize skin ulcers for bacterial infection, quantitative ultrasound (QUS) parameters were estimated by the multiple statistical analysis of the echo amplitude envelope based on both Weibull and generalized gamma distributions and the ratio of mean to standard deviation of the echo amplitude envelope. Measurement objects were three rat models (noninfection, critical colonization, and infection models). Ultrasound data were acquired using a modified ultrasonic diagnosis system with a center frequency of 11 MHz. In parallel, histopathological images and twodimensional map of speed of sound (SoS) were observed. It was possible to detect typical tissue characteristics such as infection by focusing on the relationship of QUS parameters and to indicate the characteristic differences that were consistent with the scatterer structure. Additionally, the histopathological characteristics and SoS of noninfected and infected tissues were matched to the characteristics of QUS parameters in each rat model.

Original languageEnglish
Article number07KF14
JournalJapanese Journal of Applied Physics
Volume55
Issue number7
DOIs
Publication statusPublished - 07-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint

Dive into the research topics of 'Tissue characterization of skin ulcer for bacterial infection by multiple statistical analysis of echo amplitude envelope'. Together they form a unique fingerprint.

Cite this