Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: Report of a case

Yoshiki Sawa, Shigeru Miyagawa, Taichi Sakaguchi, Tomoyuki Fujita, Akifumi Matsuyama, Atsuhiro Saito, Tatsuya Shimizu, Teruo Okano

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently, cellular therapy for end-stage heart failure has been emerging. We herein report a 56-year-old male who received a transplant of autologous myoblast sheets manufactured in temperature-responsive culture dishes. His clinical condition improved markedly, leaving him without any arrhythmia and able to discontinue using a left ventricular assist system and avoid cardiac transplantation. These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalSurgery Today
Volume42
Issue number2
DOIs
Publication statusPublished - 01-01-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

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