Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM

Report of a case

Yoshiki Sawa, Shigeru Miyagawa, Taichi Sakaguchi, Tomoyuki Fujita, Akifumi Matsuyama, Atsuhiro Saito, Tatsuya Shimizu, Teruo Okano

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently, cellular therapy for end-stage heart failure has been emerging. We herein report a 56-year-old male who received a transplant of autologous myoblast sheets manufactured in temperature-responsive culture dishes. His clinical condition improved markedly, leaving him without any arrhythmia and able to discontinue using a left ventricular assist system and avoid cardiac transplantation. These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalSurgery Today
Volume42
Issue number2
DOIs
Publication statusPublished - 01-01-2012
Externally publishedYes

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Myoblasts
Dilated Cardiomyopathy
Heart Transplantation
Heart Failure
Autografts
Cardiac Arrhythmias
Heart Diseases
Myocardium
Morbidity
Temperature
Mortality
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Sawa, Yoshiki ; Miyagawa, Shigeru ; Sakaguchi, Taichi ; Fujita, Tomoyuki ; Matsuyama, Akifumi ; Saito, Atsuhiro ; Shimizu, Tatsuya ; Okano, Teruo. / Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM : Report of a case. In: Surgery Today. 2012 ; Vol. 42, No. 2. pp. 181-184.
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Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM : Report of a case. / Sawa, Yoshiki; Miyagawa, Shigeru; Sakaguchi, Taichi; Fujita, Tomoyuki; Matsuyama, Akifumi; Saito, Atsuhiro; Shimizu, Tatsuya; Okano, Teruo.

In: Surgery Today, Vol. 42, No. 2, 01.01.2012, p. 181-184.

Research output: Contribution to journalArticle

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