Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity

Ayumi Fukakusa, Hiroyuki Mizoguchi, Hiroyuki Koike, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

Research output: Contribution to journalArticle

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Abstract

To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA-/-), and protease activated receptor-1-deficient (PAR-1-/-) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalJournal of Pharmacological Sciences
Volume106
Issue number2
DOIs
Publication statusPublished - 17-03-2008

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Methamphetamine
Tissue Plasminogen Activator
Dopamine Plasma Membrane Transport Proteins
Tyrosine 3-Monooxygenase
PAR-1 Receptor
Fever

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Fukakusa, Ayumi ; Mizoguchi, Hiroyuki ; Koike, Hiroyuki ; Nabeshima, Toshitaka ; Takuma, Kazuhiro ; Yamada, Kiyofumi. / Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. In: Journal of Pharmacological Sciences. 2008 ; Vol. 106, No. 2. pp. 321-324.
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Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. / Fukakusa, Ayumi; Mizoguchi, Hiroyuki; Koike, Hiroyuki; Nabeshima, Toshitaka; Takuma, Kazuhiro; Yamada, Kiyofumi.

In: Journal of Pharmacological Sciences, Vol. 106, No. 2, 17.03.2008, p. 321-324.

Research output: Contribution to journalArticle

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