Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity

Ayumi Fukakusa, Hiroyuki Mizoguchi, Hiroyuki Koike, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

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1 Citation (Scopus)


To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA-/-), and protease activated receptor-1-deficient (PAR-1-/-) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalJournal of Pharmacological Sciences
Issue number2
Publication statusPublished - 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology


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