Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity

Ayumi Fukakusa, Hiroyuki Mizoguchi, Hiroyuki Koike, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

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Abstract

To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA-/-), and protease activated receptor-1-deficient (PAR-1-/-) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalJournal of Pharmacological Sciences
Volume106
Issue number2
DOIs
Publication statusPublished - 17-03-2008

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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    Fukakusa, A., Mizoguchi, H., Koike, H., Nabeshima, T., Takuma, K., & Yamada, K. (2008). Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. Journal of Pharmacological Sciences, 106(2), 321-324. https://doi.org/10.1254/jphs.SC0070328