TMS motor thresholds correlate with TDCS electric field strengths in hand motor area

Marko Mikkonen, Ilkka Laakso, Motofumi Sumiya, Soichiro Koyama, Akimasa Hirata, Satoshi Tanaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Transcranial direct current stimulation (TDCS) modulates cortical activity and influences motor and cognitive functions in both healthy and clinical populations. However, there is large inter-individual variability in the responses to TDCS. Computational studies have suggested that inter-individual differences in cranial and brain anatomy may contribute to this variability via creating varying electric fields in the brain. This implies that the electric fields or their strength and orientation should be considered and incorporated when selecting the TDCS dose. Unfortunately, electric field modeling is difficult to perform; thus, a more-robust and practical method of estimating the strength of TDCS electric fields for experimental use is required. As recent studies have revealed a relationship between the sensitivity to TMS and motor cortical TDCS after-effects, the aim of the present study was to investigate whether the resting motor threshold (RMT), a simple measure of transcranial magnetic stimulation (TMS) sensitivity, would be useful for estimating TDCS electric field strengths in the hand area of primary motor cortex (M1). To achieve this, we measured the RMT in 28 subjects. We also obtained magnetic resonance images from each subject to build individual three-dimensional anatomic models, which were used in solving the TDCS and TMS electric fields using the finite element method (FEM). Then, we calculated the correlation between the measured RMT and the modeled TDCS electric fields. We found that the RMT correlated with the TDCS electric fields in hand M1 (R2 = 0.58), but no obvious correlations were identified in regions outside M1. The found correlation was mainly due to a correlation between the TDCS and TMS electric fields, both of which were affected by individual's anatomic features. In conclusion, the RMT could provide a useful tool for estimating cortical electric fields for motor cortical TDCS.

Original languageEnglish
Article number426
JournalFrontiers in Neuroscience
Volume12
Issue numberJUN
DOIs
Publication statusPublished - 25-06-2018

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Transcranial Magnetic Stimulation
Motor Cortex
Hand Strength
Transcranial Direct Current Stimulation
Anatomic Models
Brain
Individuality
Cognition
Anatomy
Motor Activity
Magnetic Resonance Spectroscopy
Hand

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Mikkonen, Marko ; Laakso, Ilkka ; Sumiya, Motofumi ; Koyama, Soichiro ; Hirata, Akimasa ; Tanaka, Satoshi. / TMS motor thresholds correlate with TDCS electric field strengths in hand motor area. In: Frontiers in Neuroscience. 2018 ; Vol. 12, No. JUN.
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TMS motor thresholds correlate with TDCS electric field strengths in hand motor area. / Mikkonen, Marko; Laakso, Ilkka; Sumiya, Motofumi; Koyama, Soichiro; Hirata, Akimasa; Tanaka, Satoshi.

In: Frontiers in Neuroscience, Vol. 12, No. JUN, 426, 25.06.2018.

Research output: Contribution to journalArticle

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AU - Laakso, Ilkka

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AU - Hirata, Akimasa

AU - Tanaka, Satoshi

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