T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells

Hui Qing Shen, Min Lu, Tomokatsu Ikawa, Kyoko Masuda, Koichiro Ohmura, Nagahiro Minato, Yoshimoto Katsura, Hiroshi Kawamoto

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

We have previously shown that the earliest thymic progenitors retain the potential to generate T and NK cells and that they lose the bipotentiality to give rise to unipotent T and NK progenitors during the progression of intrathymic developmental stages. The present study examines the ability of these thymic progenitors for generation of dendritic cells (DC) with a new clonal assay that is capable of determining the developmental potential for DC in addition to T cells and NK cells. We found that the large majority of the T/NK bipotential progenitors in the earliest population of fetal thymus was able to generate DC. Although the DC potential is lost with the progression of the differentiation stage, some of the T/NK bipotential progenitors still retain their DC potential even at the CD44+CD25+ stage.

Original languageEnglish
Pages (from-to)3401-3406
Number of pages6
JournalJournal of Immunology
Volume171
Issue number7
DOIs
Publication statusPublished - 01-10-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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