Toll-like receptor 2 - 196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer

Tomomitsu Tahara, Tomiyasu Arisawa, Fangyu Wang, Tomoyuki Shibata, Masakatsu Nakamura, Mikijyu Sakata, Ichiro Hirata, Hiroshi Nakano

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Abstract

Toll like receptors (TLR) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. The -196 to -174del polymorphism affects the TLR2 gene and alters its promoter activity. We investigated the influence of the TLR2 - 196 to - 174del polymorphism on the occurrence of non-cardiac gastric cancer (NCGC) in a Japanese population. The study was carried out with 289 patients with NCGC, 309 non-cancer patients with abdominal discomfort and 146 healthy controls. The - 196 to - 174del TLR2 polymorphism was investigated using the allele-specific polymerase chain reaction method in all of the subjects. The - 196 to - 174del/del genotype of TLR2 showed a significantly higher frequency in NCGC patients than in healthy controls (adjusted odds ratio [OR] = 6.06; 95% confidence interval [CI] = 1.86-19.72). Similarly, the frequency of the - 196 to - 174del/del genotype was significantly higher among NCGC patients than in non-cancer patients (adjusted OR = 2.02; 95% CI = 1.22-3.34). The same genotype was associated with an increased risk of both intestinal (OR = 2.00, 95% CI = 1.12-3.60) and diffuse-type (OR = 2.05; 95% CI = 1.11-3.79) histopathology. There were no significant associations between TLR2 genotypes and tumor stage and anatomical location. Our data suggest that the - 196 to - 174del/del genotype of TLR2 may increase the risk of gastric cancer in the Japanese population.

Original languageEnglish
Pages (from-to)1790-1794
Number of pages5
JournalCancer Science
Volume98
Issue number11
DOIs
Publication statusPublished - 01-11-2007

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Toll-Like Receptor 2
Stomach Neoplasms
Genotype
Odds Ratio
Confidence Intervals
Toll-Like Receptors
Population
Alleles
Polymerase Chain Reaction
Genes
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Wang, Fangyu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Sakata, Mikijyu ; Hirata, Ichiro ; Nakano, Hiroshi. / Toll-like receptor 2 - 196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. In: Cancer Science. 2007 ; Vol. 98, No. 11. pp. 1790-1794.
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abstract = "Toll like receptors (TLR) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. The -196 to -174del polymorphism affects the TLR2 gene and alters its promoter activity. We investigated the influence of the TLR2 - 196 to - 174del polymorphism on the occurrence of non-cardiac gastric cancer (NCGC) in a Japanese population. The study was carried out with 289 patients with NCGC, 309 non-cancer patients with abdominal discomfort and 146 healthy controls. The - 196 to - 174del TLR2 polymorphism was investigated using the allele-specific polymerase chain reaction method in all of the subjects. The - 196 to - 174del/del genotype of TLR2 showed a significantly higher frequency in NCGC patients than in healthy controls (adjusted odds ratio [OR] = 6.06; 95{\%} confidence interval [CI] = 1.86-19.72). Similarly, the frequency of the - 196 to - 174del/del genotype was significantly higher among NCGC patients than in non-cancer patients (adjusted OR = 2.02; 95{\%} CI = 1.22-3.34). The same genotype was associated with an increased risk of both intestinal (OR = 2.00, 95{\%} CI = 1.12-3.60) and diffuse-type (OR = 2.05; 95{\%} CI = 1.11-3.79) histopathology. There were no significant associations between TLR2 genotypes and tumor stage and anatomical location. Our data suggest that the - 196 to - 174del/del genotype of TLR2 may increase the risk of gastric cancer in the Japanese population.",
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Tahara, T, Arisawa, T, Wang, F, Shibata, T, Nakamura, M, Sakata, M, Hirata, I & Nakano, H 2007, 'Toll-like receptor 2 - 196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer', Cancer Science, vol. 98, no. 11, pp. 1790-1794. https://doi.org/10.1111/j.1349-7006.2007.00590.x

Toll-like receptor 2 - 196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Wang, Fangyu; Shibata, Tomoyuki; Nakamura, Masakatsu; Sakata, Mikijyu; Hirata, Ichiro; Nakano, Hiroshi.

In: Cancer Science, Vol. 98, No. 11, 01.11.2007, p. 1790-1794.

Research output: Contribution to journalArticle

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T1 - Toll-like receptor 2 - 196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Wang, Fangyu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Sakata, Mikijyu

AU - Hirata, Ichiro

AU - Nakano, Hiroshi

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N2 - Toll like receptors (TLR) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. The -196 to -174del polymorphism affects the TLR2 gene and alters its promoter activity. We investigated the influence of the TLR2 - 196 to - 174del polymorphism on the occurrence of non-cardiac gastric cancer (NCGC) in a Japanese population. The study was carried out with 289 patients with NCGC, 309 non-cancer patients with abdominal discomfort and 146 healthy controls. The - 196 to - 174del TLR2 polymorphism was investigated using the allele-specific polymerase chain reaction method in all of the subjects. The - 196 to - 174del/del genotype of TLR2 showed a significantly higher frequency in NCGC patients than in healthy controls (adjusted odds ratio [OR] = 6.06; 95% confidence interval [CI] = 1.86-19.72). Similarly, the frequency of the - 196 to - 174del/del genotype was significantly higher among NCGC patients than in non-cancer patients (adjusted OR = 2.02; 95% CI = 1.22-3.34). The same genotype was associated with an increased risk of both intestinal (OR = 2.00, 95% CI = 1.12-3.60) and diffuse-type (OR = 2.05; 95% CI = 1.11-3.79) histopathology. There were no significant associations between TLR2 genotypes and tumor stage and anatomical location. Our data suggest that the - 196 to - 174del/del genotype of TLR2 may increase the risk of gastric cancer in the Japanese population.

AB - Toll like receptors (TLR) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. The -196 to -174del polymorphism affects the TLR2 gene and alters its promoter activity. We investigated the influence of the TLR2 - 196 to - 174del polymorphism on the occurrence of non-cardiac gastric cancer (NCGC) in a Japanese population. The study was carried out with 289 patients with NCGC, 309 non-cancer patients with abdominal discomfort and 146 healthy controls. The - 196 to - 174del TLR2 polymorphism was investigated using the allele-specific polymerase chain reaction method in all of the subjects. The - 196 to - 174del/del genotype of TLR2 showed a significantly higher frequency in NCGC patients than in healthy controls (adjusted odds ratio [OR] = 6.06; 95% confidence interval [CI] = 1.86-19.72). Similarly, the frequency of the - 196 to - 174del/del genotype was significantly higher among NCGC patients than in non-cancer patients (adjusted OR = 2.02; 95% CI = 1.22-3.34). The same genotype was associated with an increased risk of both intestinal (OR = 2.00, 95% CI = 1.12-3.60) and diffuse-type (OR = 2.05; 95% CI = 1.11-3.79) histopathology. There were no significant associations between TLR2 genotypes and tumor stage and anatomical location. Our data suggest that the - 196 to - 174del/del genotype of TLR2 may increase the risk of gastric cancer in the Japanese population.

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