TY - JOUR
T1 - Topoisomerase i expression in tumors as a biological marker for CPT-11 chemosensitivity in patients with colorectal cancer
AU - Ikeguchi, Masahide
AU - Arai, Yosuke
AU - Maeta, Yoshihiko
AU - Ashida, Keigo
AU - Katano, Kuniyuki
AU - Wakatsuki, Toshiro
PY - 2011/9
Y1 - 2011/9
N2 - Irinotecan (CPT-11) is used as a first- and second-line chemotherapy for advanced or recurrent colorectal cancer (CRC). However, only 20%-30% of patients show an objective response to CPT-11 and the drug has severe toxicities, such as delayed-onset diarrhea, neutropenia, nausea, and vomiting. It is important to select patients who will demonstrate sensitivity to CPT-11 treatment to avoid unnecessary drug toxicities and to introduce anticancer treatment benefits to CRC patients. DNA topoisomerase I (Topo I) is essential for vital cellular processes such as DNA replication, transcription, translation, recombination, and repair. This article reviews the possibility of assessing Topo I protein expression in tumors as a biological marker for CPT-11 treatment in CRC.
AB - Irinotecan (CPT-11) is used as a first- and second-line chemotherapy for advanced or recurrent colorectal cancer (CRC). However, only 20%-30% of patients show an objective response to CPT-11 and the drug has severe toxicities, such as delayed-onset diarrhea, neutropenia, nausea, and vomiting. It is important to select patients who will demonstrate sensitivity to CPT-11 treatment to avoid unnecessary drug toxicities and to introduce anticancer treatment benefits to CRC patients. DNA topoisomerase I (Topo I) is essential for vital cellular processes such as DNA replication, transcription, translation, recombination, and repair. This article reviews the possibility of assessing Topo I protein expression in tumors as a biological marker for CPT-11 treatment in CRC.
UR - http://www.scopus.com/inward/record.url?scp=80052413958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052413958&partnerID=8YFLogxK
U2 - 10.1007/s00595-011-4546-7
DO - 10.1007/s00595-011-4546-7
M3 - Review article
C2 - 21874414
AN - SCOPUS:80052413958
SN - 0941-1291
VL - 41
SP - 1196
EP - 1199
JO - Surgery Today
JF - Surgery Today
IS - 9
ER -