Transcutaneous bilirubin monitoring predicts unexplained late-onset hemolysis in a very low birthweight infant

Miwako Nagasaka, Tomoe Kikuma, Sota Iwatani, Daisuke Kurokawa, Keiji Yamana, Kaori Maeyama, Tsubasa Koda, Hisayuki Matsumoto, Mariko Taniguchi-Ikeda, Kazumoto Iijima, Hajime Nakamura, Ichiro Morioka

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Abstract

Background: In term infants, transcutaneous bilirubin (TcB) monitoring can be used to predict hemolytic hyperbilirubinemia. However, it is not clear whether the technique can also be used to predict unexplained late-onset hemolysis in very low birthweight (VLBW) infants. Case presentation: The case was an infant with a birthweight of 1154 g who developed unexplained late-onset hemolysis at 8 days of age. The hyperbilirubinemia rapidly worsened, and therefore both phototherapy and exchange transfusion were performed. TcB levels were measured using the JM-105 jaundice meter and found to have increased by >3 mg/dL since before the onset, demonstrating for the first time that the device clearly detects changes in hemolytic rate. Conclusions: Although TcB levels did not correspond directly with total serum bilirubin levels in VLBW infants, the two values exhibited parallel changes in this case. Therefore, serial TcB monitoring may be useful in the early prediction of unexplained late-onset hemolysis in VLBW infants.

Original languageEnglish
Article number1970
JournalBMC Research Notes
Volume9
Issue number1
DOIs
Publication statusPublished - 10-03-2016

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nagasaka, M., Kikuma, T., Iwatani, S., Kurokawa, D., Yamana, K., Maeyama, K., Koda, T., Matsumoto, H., Taniguchi-Ikeda, M., Iijima, K., Nakamura, H., & Morioka, I. (2016). Transcutaneous bilirubin monitoring predicts unexplained late-onset hemolysis in a very low birthweight infant. BMC Research Notes, 9(1), [1970]. https://doi.org/10.1186/s13104-016-1970-1