Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis

Masaaki Arai, Nobuo Kondoh, Nobuo Imazeki, Akiyuki Hada, Kazuo Hatsuse, Fumihiro Kimura, Osamu Matsubara, Kazutoshi Mori, Toru Wakatsuki, Mikio Yamamoto

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


We have previously reported that the endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor 6 α (ATF6α) is implicated in the pathogenesis of hepatocellular carcinomas (HCCs). In order to further identify genes that are regulated by ATF6α, the global gene expression profiles of the ATF6α-transfected and untransfected HCC cell line, HLF, were analyzed. These results were then compared with the differential gene expression patterns of poorly differentiated HCC and control non-tumorous liver tissue. Our findings demonstrate that at least 18 genes are specifically upregulated by ATF6α, while another UPR mediator, XBP1 or ER-stress inducer, thapsigargin could partially stimulate or even repress some of them in HCC cells. Moreover, six of these identified genes contain potential ER stress-responsive elements and/or unfolded protein response elements in their 5′ regulatory regions.

Original languageEnglish
Pages (from-to)184-190
Number of pages7
JournalFEBS Letters
Issue number1
Publication statusPublished - 09-01-2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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