TY - JOUR
T1 - Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis
AU - Arai, Masaaki
AU - Kondoh, Nobuo
AU - Imazeki, Nobuo
AU - Hada, Akiyuki
AU - Hatsuse, Kazuo
AU - Kimura, Fumihiro
AU - Matsubara, Osamu
AU - Mori, Kazutoshi
AU - Wakatsuki, Toru
AU - Yamamoto, Mikio
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/1/9
Y1 - 2006/1/9
N2 - We have previously reported that the endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor 6 α (ATF6α) is implicated in the pathogenesis of hepatocellular carcinomas (HCCs). In order to further identify genes that are regulated by ATF6α, the global gene expression profiles of the ATF6α-transfected and untransfected HCC cell line, HLF, were analyzed. These results were then compared with the differential gene expression patterns of poorly differentiated HCC and control non-tumorous liver tissue. Our findings demonstrate that at least 18 genes are specifically upregulated by ATF6α, while another UPR mediator, XBP1 or ER-stress inducer, thapsigargin could partially stimulate or even repress some of them in HCC cells. Moreover, six of these identified genes contain potential ER stress-responsive elements and/or unfolded protein response elements in their 5′ regulatory regions.
AB - We have previously reported that the endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor 6 α (ATF6α) is implicated in the pathogenesis of hepatocellular carcinomas (HCCs). In order to further identify genes that are regulated by ATF6α, the global gene expression profiles of the ATF6α-transfected and untransfected HCC cell line, HLF, were analyzed. These results were then compared with the differential gene expression patterns of poorly differentiated HCC and control non-tumorous liver tissue. Our findings demonstrate that at least 18 genes are specifically upregulated by ATF6α, while another UPR mediator, XBP1 or ER-stress inducer, thapsigargin could partially stimulate or even repress some of them in HCC cells. Moreover, six of these identified genes contain potential ER stress-responsive elements and/or unfolded protein response elements in their 5′ regulatory regions.
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U2 - 10.1016/j.febslet.2005.11.072
DO - 10.1016/j.febslet.2005.11.072
M3 - Article
C2 - 16364319
AN - SCOPUS:29344457845
SN - 0014-5793
VL - 580
SP - 184
EP - 190
JO - FEBS Letters
JF - FEBS Letters
IS - 1
ER -