Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis

Masaaki Arai, Nobuo Kondoh, Nobuo Imazeki, Akiyuki Hada, Kazuo Hatsuse, Fumihiro Kimura, Osamu Matsubara, Kazutoshi Mori, Toru Wakatsuki, Mikio Yamamoto

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We have previously reported that the endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor 6 α (ATF6α) is implicated in the pathogenesis of hepatocellular carcinomas (HCCs). In order to further identify genes that are regulated by ATF6α, the global gene expression profiles of the ATF6α-transfected and untransfected HCC cell line, HLF, were analyzed. These results were then compared with the differential gene expression patterns of poorly differentiated HCC and control non-tumorous liver tissue. Our findings demonstrate that at least 18 genes are specifically upregulated by ATF6α, while another UPR mediator, XBP1 or ER-stress inducer, thapsigargin could partially stimulate or even repress some of them in HCC cells. Moreover, six of these identified genes contain potential ER stress-responsive elements and/or unfolded protein response elements in their 5′ regulatory regions.

Original languageEnglish
Pages (from-to)184-190
Number of pages7
JournalFEBS Letters
Volume580
Issue number1
DOIs
Publication statusPublished - 09-01-2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis'. Together they form a unique fingerprint.

  • Cite this

    Arai, M., Kondoh, N., Imazeki, N., Hada, A., Hatsuse, K., Kimura, F., Matsubara, O., Mori, K., Wakatsuki, T., & Yamamoto, M. (2006). Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis. FEBS Letters, 580(1), 184-190. https://doi.org/10.1016/j.febslet.2005.11.072